ZAP70 (Tyr292) Antibody, ALEXA FLUOR 647

• Catalog number
  bs-13548R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  ZAP70 (Tyr292) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-ZAP70 Tyr292 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  ZAP70 Tyr292
• Specificity
  This is a highly specific antibody against ZAP70 Tyr292.
• Modification
  Phosphorylation
• Modification Site
  Tyr292
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human Zap-70 around the phosphorylation site of Tyr292
• Gene ID Number
  7535
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  ZAP70 phospho Y292; ZAP70 phospho Tyr292; p-Zap-70Tyr292; p-Zap-70Y292; p-ZAP70 Y292; p-ZAP70 Tyr292; ZAP-70; ZAP 70; ZAP70; zeta-associated protein 70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; Syk-related tyrosine kinase. SRK; STD; TZK; ZAP70_HUMAN; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-ZAP70 Tyr292 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  ZAP70   Tyr292  
• Gene symbol
  ZAP70
• Short name
  Anti-ZAP70 Tyr292
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  ZAP70 (Tyr292) Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies
• Alternative to gene target
  zeta-chain (TCR) associated protein kinase 70kDa, SRK and STCD and STD and TZK and ZAP-70, ZAP70 and IDBG-62509 and ENSG00000115085 and 7535, transferase activity, Cell surfaces, Zap70 and IDBG-145089 and ENSMUSG00000026117 and 22637, ZAP70 and IDBG-629842 and ENSBTAG00000005892 and 504509

Gene info

• Identity
  HGNC:12858
• Gene
  ZAP70
• Long gene name
  zeta chain of T cell receptor associated protein kinase 70
• Synonyms gene
  • SRK
• Synonyms gene name
  • SRK
• Synonyms
  • ZAP-70
  • STD
• Synonyms name
  • tyrosine-protein kinase ZAP-70
• GenBank acession
  • L05148
• Locus
  2q11.2
• Discovery year
  1995-05-16
• Entrez gene record
  7535
• Pubmed identfication
  • 1423621
• RefSeq identity
  • NM_001079
• Classification
  • SH2 domain containing
  • Syk family tyrosine kinases
• VEGA ID
  OTTHUMG00000153060
• Locus Specific Databases
  • ZAP70base: Mutation registry for autosomal recessive ZAP70 immunodeficiency
  • LRG_126

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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