Anti-CD4 (Clenoliximab), Human IgG4 Antibody

• Catalog number
  A1091-200
• Price
  Please ask
• Size
  200 µg

• Antibody Target
  CD4
• Target Alternative Name
  p55; T cell surface antign T4/Leu-3.
• Antibody Type
  Monoclonal
• Clone
  CE9.1
• Species Reactivities
  Human, Chimpanzee
• Immunogen Sequence
  Domain 1 of human CD4.
• Accession
  P01730
• Gene Id
  920
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
• Purification
  Affinity purified using protein A
• Application
  ELISA; FC; Block; SPR; IHC
• Description
  The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. CD4+ T helper cell marker or cluster differentiator of white blood cells in FACS or flow cytometry. Used offer coupled to magnetic beads. GENTAUR makes custom magnetic bead couplings on 50 and 250 nm beads for certain clones.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• French translation
  anticorps

• Gene target
  CD4   Clenoliximab   IgG4  
• Gene symbol
  CD4
• Short name
  Anti-CD4 (Clenoliximab), IgG4 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Human IgG4, lambda
• Species
  Human, Humans
• Alternative name
  Antibody toCD4 (Clenoliximab), H. sapiens IgG4 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  CD4 molecule, CD4mut, CD4 and IDBG-15034 and ENSG00000010610 and 920, protein homodimerization activity, Cell surfaces, Cd4 and IDBG-188351 and ENSMUSG00000023274 and 12504, CD4 and IDBG-640247 and ENSBTAG00000003255 and 407098

Gene info

• Identity
  HGNC:1678
• Gene
  CD4
• Long gene name
  CD4 molecule
• Synonyms gene name
  • CD4 antigen (p55)
  • T-cell surface glycoprotein CD4
• GenBank acession
  • M35160
• Locus
  12p13.31
• Discovery year
  1986-01-01
• Entrez gene record
  920
• RefSeq identity
  • NM_000616
• Classification
  • CD molecules
  • C2-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000168514

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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