Mouse anti p53 (a.a. 371-380)

• Catalog number
  X1494M
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  p53 is a 53 kDa transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others.
• Antibody come from
  Synthetic peptide derived from the rat alpha1E calcium channel conjugated to KLH
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
• Clone
  Pab122
• Antigen antibody binding interaction
  Mouse anti p53 (a.a. 371-380) Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human, Mouse, Rat, Monkey, Hamster
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Immunoprecipitation, Flow Cytometry, Immunofluorescense
• Antibody s suited for
  This antibody can be used for Western blotting (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Soong,T.W et al. 'Structure and functional expression of a member of the low voltage-activated calcium channel family' Science 260 (5111), 1133-1136 (1993)_x000B__x000B_2. Chen, S. et al. 'Alpha 1E subunit of the R-type calcium channel is associated with myelinogenesis.' J. Neurocytol. 29(10), 719-28 (2000)
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  p53   371-380  
• Gene symbol
  MIR380, MIR371A
• Short name
  Mouse anti p53 (a a. 371-380)
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG2b
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to p53 (a.a. 371-380)
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:31873
• Gene
  MIR380
• Long gene name
  microRNA 380
• Synonyms gene
  • MIRN380
• Synonyms
  • hsa-mir-380
• Locus
  14q32.31
• Discovery year
  2005-01-04
• Entrez gene record
  494329
• RefSeq identity
  • NR_029872
• Classification
  • MicroRNA MIR379 family

Gene info

• Identity
  HGNC:31785
• Gene
  MIR371A
• Long gene name
  microRNA 371a
• Synonyms gene
  • MIRN371
  • MIR371
• Synonyms gene name
  • microRNA 371
• Synonyms
  • hsa-mir-371
• Locus
  19q13.42
• Discovery year
  2004-07-22
• Entrez gene record
  442916
• RefSeq identity
  • NR_029864
• Classification
  • MicroRNA MIR371 family

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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