Herbimycin A

• Catalog number
  2748-1000
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
• Description
  Herbimycin A is an ansamycin antibiotic isolated from Streptomyces sp. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2. Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity. It also inhibits angiogenesis in a rat retinopathy model.
• CAS Number
  70563-58-5
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₃₀H₄₂N₂O₉
• Molecular Weight
  574.7
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 6 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent protein tyrosine kinase (PTK) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD00151702
• PubChem CID
  6436247
• PubChem CID Link
• SMILES
  CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC
• InChi
  InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9+,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
• InChi Key
  MCAHMSDENAOJFZ-GDYSMBPZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Herbimycin  
• Short name
  Herbimycin A
• Alternative name
  Herbimycin A

Product images

Similar products