BSI 201, PARP1 inhibitor

  • Catalog number
    SIH-539-10MG
  • Price
    Please ask
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    160003-66-7
  • Description
    PARP1 inhibitor
  • Molecular weight
    292 g/mol
  • Primary research fields
    Cancer, Cancer Growth Inhibitors
  • Other name
    Iniparib, 4-Iodo-3-nitrobenzamide, BSI-201, 4-iodo-3-nitro-benzamide, Iniparib (BSI-201)
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C7H5IN2O3
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble in DMSO (5 mg/ml)
  • Physical appearance
    White to beige powder
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: D2B Toxic Material Causing Other Toxic Effects - Moderate eye irritant Hazard statement(s): H302 Harmful if swallowed. H319 Causes serious eye irritation. Precautionary statement(s): P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • PubChem number
    9796068
  • Scientific context
    BSI 201 is a small molecule PARP1 inhibitor. It is cytotoxic in cells with DNA alterations or DNA damage, thereby inhibiting the growth of tumor cells.
  • Release date
    30/Aug/2016
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of BSI 201 (SIH-539), a PARP1 inhibitor. CAS #: 160003-66-7. Molecular Formula: C7H5IN2O3. Molecular Weight: 292 g/mol. Chemical structure of BSI 201, a PARP1 inhibitor (SIH-539). CAS # 160003-66-7. Molecular Formula: C7H5IN2O3.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
    BSI   201   PARP1   inhibitor  
  • Gene symbol
    PARP1
  • Short name
    BSI 201, PARP1 inhibitor
  • Alternative name
    BSI 201, PARP1 suppressor
Gene info
  • Identity
  • Gene
  • Long gene name
    poly(ADP-ribose) polymerase 1
  • Synonyms gene
  • Synonyms gene name
    • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
    • poly (ADP-ribose) polymerase family, member 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1986-01-01
  • Entrez gene record
    142
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Zinc fingers PARP-type
    • Zinc fingers
    • Poly(ADP-ribose) polymerases
  • VEGA ID
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