BSI 201, PARP1 inhibitor
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Catalog numberSIH-539-10MG
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PricePlease ask
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Size10 mg
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Stock availabilitIn StockIn Stock
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CAS number160003-66-7
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DescriptionPARP1 inhibitor
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Molecular weight292 g/mol
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Primary research fieldsCancer, Cancer Growth Inhibitors
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Other nameIniparib, 4-Iodo-3-nitrobenzamide, BSI-201, 4-iodo-3-nitro-benzamide, Iniparib (BSI-201)
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC7H5IN2O3
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OriginSynthetic
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Purity pourcentage>98%
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Soluble inSoluble in DMSO (5 mg/ml)
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Physical appearanceWhite to beige powder
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: D2B Toxic Material Causing Other Toxic Effects - Moderate eye irritant Hazard statement(s): H302 Harmful if swallowed. H319 Causes serious eye irritation. Precautionary statement(s): P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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PubChem number9796068
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Scientific contextBSI 201 is a small molecule PARP1 inhibitor. It is cytotoxic in cells with DNA alterations or DNA damage, thereby inhibiting the growth of tumor cells.
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Release date30/Aug/2016
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of BSI 201 (SIH-539), a PARP1 inhibitor. CAS #: 160003-66-7. Molecular Formula: C7H5IN2O3. Molecular Weight: 292 g/mol. Chemical structure of BSI 201, a PARP1 inhibitor (SIH-539). CAS # 160003-66-7. Molecular Formula: C7H5IN2O3.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.01
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolPARP1
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Short nameBSI 201, PARP1 inhibitor
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Alternative nameBSI 201, PARP1 suppressor
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Gene info
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Identity
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Gene
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Long gene namepoly(ADP-ribose) polymerase 1
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Synonyms gene
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Synonyms gene name
- ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
- poly (ADP-ribose) polymerase family, member 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers PARP-type
- Zinc fingers
- Poly(ADP-ribose) polymerases
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VEGA ID