Vinorelbine Tartrate

• Catalog number
  1957-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate
• Description
  A semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.
• CAS Number
  125317-39-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₄₅H₅₄N₄O₈.C₈H₁₂O₁₂
• Molecular Weight
  1079.11
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  Water (~ 10 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  An anti-mitotic and antitumor agent
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• MDL Number
  MFCD03613607
• PubChem CID
  607791
• PubChem CID Link
• SMILES
  CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9) (C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C (=O)O)O)(C(=O)O)O
• InChi
  InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6, 36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32) 54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2, 37(43)49)39(57-26(3)50)45(38, 53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9, 16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28?,37-,38+,39+,42+,43+, 44-,45-;2*1-,2-/m011/s1
• InChi Key
  CILBMBUYJCWATM-NPJYPKOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Vinorelbine   Tartrate  
• Short name
  Vinorelbine Tartrate
• Alternative name
  Vinorelbine Tartrate

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