Vinorelbine Tartrate
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Catalog number1957-5
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PricePlease ask
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Size5 mg
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Alternative_name3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate
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DescriptionA semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.
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CAS Number125317-39-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₄₅H₅₄N₄O₈.C₈H₁₂O₁₂
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Molecular Weight1079.11
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesWater (~ 10 mg/ml)
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HandlingProtect from light and moisture
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Tag LineAn anti-mitotic and antitumor agent
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life48 months
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MDL NumberMFCD03613607
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PubChem CID607791
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SMILESCCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9) (C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C (=O)O)O)(C(=O)O)O
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InChiInChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6, 36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32) 54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2, 37(43)49)39(57-26(3)50)45(38, 53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9, 16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28?,37-,38+,39+,42+,43+, 44-,45-;2*1-,2-/m011/s1
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InChi KeyCILBMBUYJCWATM-NPJYPKOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameVinorelbine Tartrate
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Alternative nameVinorelbine Tartrate
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