Mouse anti Caspase-7
-
Catalog numberX1267M
-
PricePlease ask
-
Size100 μg
-
-
CategoryPrimary Antibodies
-
Long descriptionCaspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 is a 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in three varient forms. Granzyme B activates pro-caspase-7 to a form which can cleave poly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivo caspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7 has been shown to exist as dimers or high order oligomers. Caspase-7 may be an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic T-lymophocyte-induced cell killing in vivo.
-
Antibody come fromn/a
-
Other descriptionProtein A/G Chromatography
-
CloneMCH3-5
-
Antigen antibody binding interactionMouse anti Caspase-7 Antibody
-
Antibody is raised inMouse
-
Antibody s reacts withHuman
-
Antibody s reacts with these speciesThis antibody doesn't cross react with other species
-
Antibody s specificityNo Data Available
-
ApplicationWestern Blot
-
Antibody s suited forOptimal concentration should be evaluated by serial dilutions.
-
Storage-20ºC
-
Relevant referencesno information yet
-
Protein numbersee ncbi
-
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
-
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin nameMus musculus
-
Gene target
-
Gene symbolCASP7, MZB1
-
Short nameMouse anti Caspase-7
-
TechniqueMouse, anti, antibody to, mouses
-
Hostmouse
-
IsotypeIgG
-
Labelunlabeled
-
SpeciesMouse, Mouses
-
Alternative nameMouse antibody to caspase-7
-
Alternative techniquemurine, antibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namecaspase 7
-
Synonyms gene name
- caspase 7, apoptosis-related cysteine protease
- caspase 7, apoptosis-related cysteine peptidase
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1996-07-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Caspases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemarginal zone B and B1 cell specific protein
-
Synonyms gene name
- marginal zone B and B1 cell-specific protein
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2012-09-19
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data