anti-Hrk Antibody

• Catalog number
  3771
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Hrk Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
• Gene names
  Hrk Antibody: DP5, HARAKIRI, BID3, Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3
• Antibodie s label
  unlabelled serum
• Purity
  Hrk Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  HRK antibody was made against a 15 amino acid synthetic peptide from near the center of human Hrk.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  Hrk antibody can be used for the detection of Hrk by Western blot at 2.5 - 5 ug/mL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.
• Suspention pH azide
  Hrk Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Hrk antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse
• Omim nr
  4504493
• Ncbi nr
  NP_003797
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  8739
• GENE symbol
  HRK
• Antigene name
  harakiri, BCL2 interacting protein (contains only BH3 domain)
• Source
  Homo sapiens
• Protein nr
  O00198
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Hrk  
• Gene symbol
  HRK
• Short name
  anti-Hrk Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toHrk (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  harakiri, BCL2 interacting protein (contains only BH3 domain), DP5 and HARAKIRI, HRK and IDBG-59297 and ENSG00000135116 and 8739, protein binding, Plasma membranes, Hrk and IDBG-195140 and ENSMUSG00000046607 and 12123, HRK and IDBG-633660 and ENSBTAG00000047484 and 787139

Gene info

• Identity
  HGNC:5185
• Gene
  HRK
• Long gene name
  harakiri, BCL2 interacting protein
• Synonyms gene name
  • harakiri, BCL2-interacting protein (contains only BH3 domain)
• Synonyms
  • DP5
• Synonyms name
  • death protein 5
• GenBank acession
  • U76376
• Locus
  12q24.22
• Discovery year
  1999-05-21
• Entrez gene record
  8739
• Pubmed identfication
  • 9130713
• Classification
  • BCL2 homology region 3 (BH3) only
• VEGA ID
  OTTHUMG00000169328

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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