GDF-8/Myostatin/MSTN

• Catalog number
  E21-J43
• Price
  Please ask
• Size
  10ug

• Shipping_Temperature
  Ambient
• Product_State
  Lyophilized
• Formulation_Description
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Storage
  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Background
  Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues.
• Alternative Names
  Growth/differentiation factor 8;GDF-8;Myostatin;Mstn;Gdf8
• Expression system
  Human cells

• Gene target
  GDF-8/Myostatin/MSTN  
• Gene symbol
  MSTN, SNORD114-8, RNU6-8, SNORD113-8, SNORD116-8, IGKV2OR2-8, MIR1302-8, PIRC35
• Short name
  GDF-8/Myostatin/MSTN
• Species
  Human
• Alternative name
  GDF-8/Myostatin/myostatin
• Alternative to gene target
  myostatin, GDF8 and MSLHP, MSTN and IDBG-77438 and ENSG00000138379 and 2660, identical protein binding, Extracellular, Mstn and IDBG-153903 and ENSMUSG00000026100 and 17700, MSTN and IDBG-639462 and ENSBTAG00000011808 and 281187

Gene info

• Identity
  HGNC:4223
• Gene
  MSTN
• Long gene name
  myostatin
• Synonyms gene
  • GDF8
• Synonyms gene name
  • growth differentiation factor 8
• GenBank acession
  • AF019627
• Locus
  2q32.2
• Discovery year
  1997-09-12
• Entrez gene record
  2660
• Pubmed identfication
  • 9288100
  • 10610713
  • 17003236
• RefSeq identity
  • NM_005259
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000132663
• Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_200

Gene info

• Identity
  HGNC:32996
• Gene
  SNORD114-8
• Long gene name
  small nucleolar RNA, C/D box 114-8
• Synonyms
  • 14q(II-8)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767584
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003200.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:34285
• Gene
  RNU6-8
• Long gene name
  RNA, U6 small nuclear 8
• Synonyms
  • U6-8
• Locus
  14q12
• Discovery year
  2008-06-10
• Entrez gene record
  101954278
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_104088
• Classification
  • Small nuclear RNAs

Gene info

• Identity
  HGNC:32987
• Gene
  SNORD113-8
• Long gene name
  small nucleolar RNA, C/D box 113-8
• Synonyms
  • 14q(I-8)
• Locus
  14q32.31
• Discovery year
  2006-09-20
• Entrez gene record
  767568
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003236.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33074
• Gene
  SNORD116-8
• Long gene name
  small nucleolar RNA, C/D box 116-8
• Synonyms
  • HBII-85-8
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033420
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003323
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5811
• Gene
  IGKV2OR2-8
• Long gene name
  immunoglobulin kappa variable 2/OR2-8 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2/OR2-8
  • immunoglobulin kappa variable 2/OR2-8 pseudogene
• Synonyms
  • IGKV2/OR2-8
• GenBank acession
  • X51880
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  100996600
• RefSeq identity
  • NG_011662
• Classification
  • Immunoglobulin kappa (IGK) orphons

Gene info

• Identity
  HGNC:35300
• Gene
  MIR1302-8
• Long gene name
  microRNA 1302-8
• Synonyms gene
  • MIRN1302-8
• Synonyms
  • hsa-mir-1302-8
• Locus
  9q22.33
• Discovery year
  2008-11-03
• Entrez gene record
  100302223
• RefSeq identity
  • NR_031637
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37539
• Gene
  PIRC35
• Long gene name
  piwi-interacting RNA cluster 35
• Locus
  8
• Discovery year
  2009-11-05
• Entrez gene record
  100313855
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

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