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GDF 8 Myostatin

GDF 8 Myostatin is available 2 times from Enogene labs

E21-783 | GDF-8/Myostatin size: 10ug | 445.88 USD

Catalog number E21-783
Supplier EnoGene
Price 445.88 USD
Size 10ug
Background Mouse Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues. Experiments in mice have improved that GDF-8 is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking Myostatin encoding gene show decreased body fat and a generalized increase in bone density and strength.
Gene targetGDF-8/Myostatin
Short name GDF-8/Myostatin
Species Mouse
Alternative name GDF-8/Myostatin
1. Gene info
Identity 34285
Gene RNU6-8
Long gene name RNA, U6 small nuclear 8
Synonyms
  • U6-8
Locus 14q12
Discovery year 2008-06-10
Entrez gene record 101954278
Pubmed identfication
  • 12711679
RefSeq identity
  • NR_104088
Classification
  • Small nuclear RNAs
2. Gene info
Identity 4223
Gene MSTN
Long gene name myostatin
Synonyms gene
  • GDF8
Synonyms gene name
  • growth differentiation factor 8
GenBank acession
  • AF019627
Locus 2q32.2
Discovery year 1997-09-12
Entrez gene record 2660
Pubmed identfication
  • 9288100
  • 10610713
  • 17003236
RefSeq identity
  • NM_005259
Classification
  • Transforming growth factor beta superfamily
Havana BLAST/BLAT OTTHUMG00000132663
Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_200

E21-J43 | GDF-8/Myostatin/MSTN size: 10ug | 445.88 USD

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Shipping_Temperature Ambient
Product_State Lyophilized
Formulation_Description Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Alternative Names Growth/differentiation factor 8;GDF-8;Myostatin;Mstn;Gdf8
Expression system Human cells
Alternative to gene target myostatin, GDF8 and MSLHP, MSTN and IDBG-77438 and ENSG00000138379 and 2660, identical protein binding, Extracellular, Mstn and IDBG-153903 and ENSMUSG00000026100 and 17700, MSTN and IDBG-639462 and ENSBTAG00000011808 and 281187
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