EX-527,SIRT1 inhibitor

Research Area s

Cell Signaling , Epigenetics
Category

Small Molecules
Product Type

Inhibitor
CAS No

49843-98-3
MolecularFormula

C13H13ClN2O
Molecular Weight

248.7
Purity

>98% (TLC), NMR conforms
Solubility

Soluble in 18 mg/ml DMSO or 10 mg/ml Ethanol
Appearance

Light Yellow Solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

EX-527 SIRT1 inhibitor
Gene symbol

SIRT1, SIRT1-AS, MIR527
Short name

EX-527 SIRT1 inhibitor
Alternative name

EX-527,sirtuin 1 suppressor
Alternative to gene target

sirtuin 1, SIR2L1, SIRT1 and IDBG-75847 and ENSG00000096717 and 23411, keratin filament binding, nuclei, Sirt1 and IDBG-159441 and ENSMUSG00000020063 and 93759, SIRT1 and IDBG-629119 and ENSBTAG00000014023 and 613629

Identity

HGNC:14929
Gene

SIRT1
Long gene name

sirtuin 1
Synonyms gene name
- sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1
- sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Synonyms
- SIR2L1
GenBank acession
- AF083106
Locus

10q21.3
Discovery year

2001-03-20
Entrez gene record

23411
Pubmed identfication
- 10381378
RefSeq identity
- NM_012238
Classification
- eNoSC complex
- Sirtuins
VEGA ID

OTTHUMG00000018340