MPEP hydrochloride

• Catalog number
  B1151-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  2-Methyl-6-(phenylethynyl)pyridine hydrochloride
• Description
  MPEP hydrochloride is a highly selective and potent non-competitive antagonist at the mGlu5 (metabotropic glutamate receptor subtype 5) receptor subtype (IC₅₀ = 36 nM). It is a positive allosteric modulator at mGlu4. MPEP hydrochloride reduces DHPG (S-3, 5-dihydroxyphenylglycine)-induced excitations but not the excitations induced by AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). In vivo studies show it reverses mechanical hyperalgesia in the inflamed rat hind paw.
• CAS Number
  219911-35-0
• Structure Available
  Yes
• Salt Form
  Yes
• Molecular Formula
  C₁₄H₁₁N.HCl
• Molecular Weight
  229.71
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A highly selective and potent non-competitive antagonist at the mGlu5
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD02262119
• PubChem CID
  9794588
• PubChem CID Link
• SMILES
  CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl
• InChi
  1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
• InChi Key
  PKDHDJBNEKXCBI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  MPEP   hydrochloride  
• Short name
  MPEP hydrochloride
• Alternative name
  MPEP hydrochloride

Product images

Similar products