Tozasertib (VX-680, MK-0457, VX6)
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Catalog number1595-25
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PricePlease ask
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Size25 mg
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Alternative_nameMK-0457, VX6, VX-681
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DescriptionTozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.
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CAS Number639089-54-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaCāāHāāNāOS
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Molecular Weight464.59
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Cell PermeableYes
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Purityā„99% by HPLC
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SolubilitiesDMSO (100 mg/ml)
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HandlingProtect from light and moisture
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Tag LineAn Aurora kinase inhibitor
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Storage Condition-20Ā°C
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Shipping ConditionRT
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Shelf Life24months
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MDL NumberMFCD10565966
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PubChem CID5494449
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SMILESCC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
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InChiInChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12- 31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H, 3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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InChi KeyGCIKSSRWRFVXBI-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolMVK, STYXL1, MDK, MAPKAPK3, EPCAM
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Short nameTozasertib (VX-680, MK-0457, VX6)
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Alternative nameTozasertib (VX-680, MK-0457, VX6)
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Gene info
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Identity
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Gene
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Long gene namemevalonate kinase
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Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-10-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameserine/threonine/tyrosine interacting like 1
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Synonyms gene
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Synonyms gene name
- dual specificity phosphatase 24 (putative)
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MAP kinase phosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemidkine
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Synonyms gene
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Synonyms gene name
- neurite growth-promoting factor 2
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Synonyms
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Locus
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Discovery year1991-07-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMAPK activated protein kinase 3
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Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-03-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MAPK activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameepithelial cell adhesion molecule
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-10-02
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Entrez gene record
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Pubmed identfication
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Classification
- MicroRNA protein coding host genes
- CD molecules
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VEGA ID
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Locus Specific Databases