Amidepsine D, Humcola sp.

Alternative_name

N-[4-[[4-[(2,4-Dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoyl]oxy]-2-hydroxy-6-methylbenzoic acid
Description

An inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC₅₀ = 17.5 µM) and Raji cells (IC₅₀ = 2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
CAS Number

79786-34-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₆H₂₄NO₁₀
Molecular Weight

496.48
Cell Permeable

Yes
Purity

≥95% by HPLC
Solubilities

DMSO or EtOH
Handling

Protect from air and light
Tag Line

A diacylglycerol acyltransferase (DGAT) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24months
PubChem CID

10391109
PubChem CID Link
SMILES

CC1=CC(=CC(=C1C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O
InChi

InChI=1S/C26H24O10/c1-12-7-16(9-18(27)21(12)24(29)30)35-25(31)22-13(2)8-17(10-19(22)28)36-26(32)23-14(3)6-15(33-4)11-20(23)34-5/h6-11,27-28H,1-5H3,(H,29,30)
InChi Key

KODVVMZOLYYCMV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes