Brefeldin A, GEF inhibitor
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Catalog numberSIH-225-5MG
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PricePlease ask
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Size5 mg
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Stock availabilitIn StockIn Stock
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CAS number20350-15-6
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DescriptionGEF inhibitor
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Molecular weight280,36 g/mol
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Primary research fieldsCancer, Apoptosis
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Other nameCyanaein
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC16H24O4
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OriginSynthetic
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Purity pourcentage>98%
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Soluble inSoluble to 10 mM in ethanol and to 50 mM in DMSO
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Physical appearanceWhite Crystalline Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects Hazard Phrases: H301 Precautionary Phrases: P301 + P310
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PubChem number5287620
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Scientific contextBrefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).
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Bibliography1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.
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Release date8-Apr-2011
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of Brefeldin A (SIH-225), a Inhibits intracellular transport. CAS #: 20350-15-6. Molecular Formula: C16H24O4. Molecular Weight: 280.36 g/mol. Chemical structure of Brefeldin A, a Inhibits intracellular transport (SIH-225). CAS # 20350-15-6. Molecular Formula: C16H24O4.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.005
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolRAPGEF5, RAPGEF6, ARHGEF2, RAPGEF2, SLC2A4RG
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Short nameBrefeldin A, GEF inhibitor
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Alternative nameBrefeldin A, GEF suppressor
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Gene info
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Identity
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Gene
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Long gene nameRap guanine nucleotide exchange factor 5
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Synonyms gene name
- Rap guanine nucleotide exchange factor (GEF) 5
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-03-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRap guanine nucleotide exchange factor 6
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Synonyms gene
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Synonyms gene name
- PDZ domain containing guanine nucleotide exchange factor (GEF) 2
- Rap guanine nucleotide exchange factor (GEF) 6
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-09-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PDZ domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRho/Rac guanine nucleotide exchange factor 2
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Synonyms gene name
- rho/rac guanine nucleotide exchange factor (GEF) 2
- Rho/Rac guanine nucleotide exchange factor (GEF) 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Dbl family Rho GEFs
- Pleckstrin homology domain containing
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRap guanine nucleotide exchange factor 2
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Synonyms gene
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Synonyms gene name
- PDZ domain containing guanine nucleotide exchange factor (GEF) 1
- Rap guanine nucleotide exchange factor (GEF) 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-05-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
- PDZ domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSLC2A4 regulator
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID