AG 1478, EGFR kinase inhibitor

  • Catalog number
    SIH-425-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    153436-53-4
  • Description
    EGFR kinase inhibitor
  • Molecular weight
    315,8 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine, 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C16H14ClN3O2
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (HPLC)
  • Soluble in
    Soluble in DMSO (10 mg/ml)
  • Physical appearance
    White to light yellow solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    2051
  • Scientific context
    AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.
  • Bibliography
    1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053. 2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of AG 1478 (SIH-425), a EGFR kinase inhibitor. CAS #: 175178-82-2. Molecular Formula: C16H14ClN3O2. Molecular Weight: 315.8 g/mol. Chemical structure of AG 1478, a EGFR kinase inhibitor (SIH-425). CAS # 175178-82-2. Molecular Formula: C16H14ClN3O2.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
    1478   EGFR   kinase   inhibitor  
  • Gene symbol
    EGFR-AS1, EGILA, EGFR, RHBDF1
  • Short name
    AG 1478, EGFR kinase inhibitor
  • Alternative name
    AG 1478, epidermal growth factor receptor phosphorylation catalyst suppressor
  • Alternative to gene target
    epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    EGFR interacting lncRNA
  • Synonyms
  • Locus
  • Discovery year
    2019-09-27
  • Pubmed identfication
  • Classification
    • Long non-coding RNAs with non-systematic symbols
Gene info
Gene info
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