RS-1

Alternative_name

4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Description

RS-1 (RAD51-stimulatory compound 1) is a high affinity stimulator of the human homologous recombination (HR) protein RAD51. RS-1 stimulates binding of hRAD51 to single stranded DNA (ssDNA) and enhances recombinogenic activity by stabilizing the active form of hRAD51 filaments without inhibiting hRAD51 ATPase activity. RS-1 has been shown to enhance CRISPR-Cas9 knock-in efficiency in HEK293A cells and has been shown to enhance both TALEN and Cas9-mediated knock-in efficiency in rabbits.
CAS Number

312756-74-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₁₆Br₂N₂O₃S
Molecular Weight

524.23
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>50 mg/ml)
Handling

Protect from air and light
Tag Line

A RAD51 stimulator and HDR enhancer
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD00348720
PubChem CID

1039737
PubChem CID Link
SMILES

C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br
InChi

InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
InChi Key

SWKAVEUTKGKHSR-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

RS-1
Gene symbol

RS1, RSC1A1, SDSL, REG1CP, RACK1, PTENP1, RHBDF1, ZRSR2P1, PITX2, IGHVII-1-1
Short name

RS-1
Alternative name

RS-1

Identity

HGNC:9953
Gene

REG1CP
Long gene name

regenerating family member 1 gamma, pseudogene
Synonyms gene
- REGL
- REG1P
Synonyms gene name
- rat regenerating islet-derived-like, human homolog (pancreatic stone protein-like, pancreatic thread protein-like)
- regenerating islet-derived-like, pancreatic stone protein-like, pancreatic thread protein-like (rat)
- regenerating islet-derived 1 pseudogene
Synonyms
- RS
Locus

2p12
Discovery year

1993-07-12
Entrez gene record

5969
Pubmed identfication
- 8333731
RefSeq identity
- NR_002714
VEGA ID

OTTHUMG00000152978

Identity

HGNC:4399
Gene

RACK1
Long gene name

receptor for activated C kinase 1
Synonyms gene
- GNB2L1
Synonyms gene name
- guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Synonyms
- Gnb2-rs1
- H12.3
GenBank acession
- M24194
Locus

5q35.3
Discovery year

1999-10-19
Entrez gene record

10399
Pubmed identfication
RefSeq identity
- NM_006098
Classification
- Small nucleolar RNA protein coding host genes
- WD repeat domain containing
- SSU processome
VEGA ID

OTTHUMG00000163380

Identity

HGNC:20561
Gene

RHBDF1
Long gene name

rhomboid 5 homolog 1
Synonyms gene
- C16orf8
Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
Synonyms
- EGFR-RS
- FLJ2235
- Dist1
- iRhom1
GenBank acession
- BC014425
Locus

16p13.3
Discovery year

2003-04-07
Entrez gene record

64285
Pubmed identfication
- 8318735
- 15965977
RefSeq identity
- NM_022450
Classification
- Rhomboid family
VEGA ID

OTTHUMG00000060719

Identity

HGNC:12456
Gene

ZRSR2P1
Long gene name

ZRSR2 pseudogene 1
Synonyms gene
- U2AFBPL
- U2AF1P
- U2AF1L1
- ZRSR1
Synonyms gene name
- U2(RNU2) small nuclear RNA auxiliary factor binding protein-like
- U2 small nuclear RNA auxillary factor 1-like 1
- zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1
Synonyms
Synonyms name
- U2(RNU2) small nuclear RNA auxiliary factor pseudogene 1
GenBank acession
- D49676
Locus

5q22.2
Discovery year

1994-07-13
Entrez gene record

7310
Pubmed identfication
- 7956352
RefSeq identity
- NG_005419
Classification
- RNA binding motif containing
VEGA ID

OTTHUMG00000163143

Identity

HGNC:9005
Gene

PITX2
Long gene name

paired like homeodomain 2
Synonyms gene
- IRID2
- IHG2
- RIEG
- RIEG1
- RGS
Synonyms gene name
- paired-like homeodomain transcription factor 2
- paired-like homeodomain 2
Synonyms
- IGDS
- RS
- Brx1
- Otlx2
- ARP1
GenBank acession
- U69961
Locus

4q25
Discovery year

1992-10-05
Entrez gene record

5308
Pubmed identfication
- 9539779
- 7581385
Classification
- PRD class homeoboxes and pseudogenes
VEGA ID

OTTHUMG00000132837

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325