N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide; Defactinib; VS-6063
PF-04554878 is potent, ATP-competitive, focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. PF-04554878 inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. A combination of PF-04554878 and paclitaxel markedly decreases proliferation and increases apoptosis.
Is it cell-permeable?
≥98% by HPLC
Is this a salt?
Protect from air and light
Maximum time for storage
DMSO (~40 mg/ml)
For cells, cell lines and tissues in culture till half confluency.