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Human CellExp EPOR Erythropoietin Receptor human recombinant

Human CellExp EPOR Erythropoietin Receptor human recombinant is available 4 times from Biovision labs

7454-10 | Human CellExp EPOR/Erythropoietin Receptor, human recombinant size: 10 μg | 388.84 USD

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7454-50 | Human CellExp EPOR/Erythropoietin Receptor, human recombinant size: 50 μg | 877.83 USD

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7454-10 | Human CellExp™ EPOR/Erythropoietin Receptor, human recombinant size: 10 μg | 289.86 USD

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7454-50 | Human CellExp™ EPOR/Erythropoietin Receptor, human recombinant size: 50 μg | 821.28 USD

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Target EPOR/Erythropoietin Receptor
Background Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR pre-exists as dimers which upon binding of a 34 kDa ligand erythropoietin (EPO), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor. Erythropoietin is necessary to maintain endothelial cells and to promote tumor angiogenesis, hence the dysregulation of EpoR may affect the growth of certain tumors. EpoR signaling prevents neuronal death and ischemic injury.
Concentration N/A
Molecular weight This protein is fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 50.1 kDa. The predicted N-terminus is Ala 25. DTT-reduced Protein migrates as 55-60 kDa due to glycosylation.
Synonym EPOR, Erythropoietin Receptor.
Other name EPOR, Erythropoietin Receptor.
NCBI gene number 2057
NCBI gene EPOR
Gene source Human
NCBI number P19235
Recombinant Yes
Source HEK293 cells
Purification ≥92%
Tested applications SDS-PAGE, N/A
Tested activity N/A
Biological activity Measured by its ability to inhibit Epo-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is typically 2 - 6 ng/ml in the presence of 0.2 U/ml of rhEpo-Fc.
Reesults Measured by its ability to inhibit Epo-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is typically 2 - 6 ng/ml in the presence of 0.2 U/ml of rhEpo-Fc.
Binding ability N/A
Unit N/A
Storage condition -20°C
Shipping under Gel Pack
Physical appearance Lyophilized
Physical properties Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
How to reconstitute Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Aa sequence N/A
Before use Centrifuge the vial prior to opening.
Notes For Research Use Only! Not to be used in humans
Synonyms EPOR, Erythropoietin Receptor.
Alternates names EPOR, Erythropoietin Receptor.
Taglines A major glycoprotein hormone regulator of mammalian erythropoiesis
Biomolecule/Target EPOR/Erythropoietin Receptor
NCBI Gene ID #. 2057
NCBI Gene Symbol EPOR
Gene Source Human
Accession # P19235
Purity N/A
Activity (Specifications/test method) N/A
Results Measured by its ability to inhibit Epo-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is typically 2 - 6 ng/ml in the presence of 0.2 U/ml of rhEpo-Fc.
Molecular Weight This protein is fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 50.1 kDa. The predicted N-terminus is Ala 25. DTT-reduced Protein migrates as 55-60 kDa due to glycosylation.
Storage Temp. -20°C
Shipping Gel Pack
Shelf Life 1 year
Appearance Lyophilized
Physical form description Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Additional source Recombinants or rec. proteins
Group recombinants
Technique Recombinant
Alternative technique rec
Alternative to gene target erythropoietin receptor, EPO-R, EPOR and IDBG-29281 and ENSG00000187266 and 2057, identical protein binding, Extracellular, Epor and IDBG-142378 and ENSMUSG00000006235 and 13857, EPOR and IDBG-643528 and ENSBTAG00000008197 and 281144
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Human CellExp EPOR Erythropoietin Receptor human recombinant
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  • CellExp
  • EPOR/Erythropoietin
  • Receptor
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