LAMC2 Antibody

• Catalog number
  R30659
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  LAMC2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the LAMC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This LAMC2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q13753
• Purity
  Antigen affinity
• Description
  Laminin subunit gamma-2 is a protein that in humans is encoded by the LAMC2 gene. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. This gene encodes the gamma chain isoform laminin, gamma2. The gamma2 chain, formerly though to be a truncated version of beta chain(B2t), is highly homologous to the gamma1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma1, and is specifically localized to epithelial cells in skin, lung and kidney. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized.
• Immunogen
  An amino acid sequence from the C-terminus of LAMC2 (ETSIDGILADVKNLENIRDNL) was used as the immunogen for this LAMC2 antibody (100% homologous in human, mouse and rat).
• Storage
  After reconstitution, the LAMC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LAMC2  
• Gene symbol
  LAMC1-AS1, LAMC2
• Short name
  Anti-LAMC2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to LAMC2
• Alternative technique
  antibodies
• Alternative to gene target
  laminin, gamma 2, B2T and BM600 and CSF and EBR2 and EBR2A and LAMB2T and LAMNB2, LAMC2 and IDBG-105293 and ENSG00000058085 and 3918, heparin binding, Extracellular, Lamc2 and IDBG-198823 and ENSMUSG00000026479 and 16782, LAMC2 and IDBG-637198 and ENSBTAG00000000793 and 511043

Gene info

• Identity
  HGNC:52645
• Gene
  LAMC1-AS1
• Long gene name
  LAMC1 antisense RNA 1
• Synonyms
  • lnc-LAMC2-1:1
• Locus
  1q25.3
• Discovery year
  2017-08-03
• Entrez gene record
  110841583
• Pubmed identfication
  • 26905585
  • 28032728
• RefSeq identity
  • NR_149048
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:6493
• Gene
  LAMC2
• Long gene name
  laminin subunit gamma 2
• Synonyms gene
  • EBR2
  • LAMB2T
  • LAMNB2
  • EBR2A
• Synonyms gene name
  • laminin, gamma 2 (nicein (100kD), kalinin (105kD), BM600 (100kD), Herlitz junctional epidermolysis bullosa))
  • laminin, gamma 2
• Synonyms
  • nicein-100kDa
  • kalinin-105kDa
  • BM600-100kDa
• GenBank acession
  • Z15008
• Locus
  1q25.3
• Discovery year
  1993-07-13
• Entrez gene record
  3918
• Pubmed identfication
  • 1383240
• RefSeq identity
  • NM_005562
• Classification
  • Laminin subunits
• VEGA ID
  OTTHUMG00000035520

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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