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Anti-MGLUR2/3 (Polyclonal), ALEXA Fluor 594

Anti-MGLUR2/3 (Polyclonal), ALEXA Fluor 594 is available 0 time from Bioss polyclonal antibodies labs

Modification No modification has been applied to this antibody
Clonality Polyclonal Antibody
Other name Anti-MGLUR2/3 Polyclonal
Host organism Rabbit (Oryctolagus cuniculus)
Background information L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Also known as MGLUR2/3 Polyclonal Antibody
Swiss Prot Q14416, Q14832
Specificity This antibody reacts specifically with MGLUR2/3
Modification site None
Applications with corresponding dilutions IF(IHC-P)(1:50-200)
Conjugated with ALEXA FLUOR® 594
Gene ID 2913, 2912
Clone Polyclonal Antibodies
Cross Reactive Species details No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
Synonyms Metabotropic glutamate receptor 3; mGluR3; GRM3; GPRC1C; Metabotropic glutamate receptor 2; mGluR2; GRM2; GPRC1B
Applications IF(IHC-P)
Subcellular locations Extracellular
Concentration 1ug per 1ul
Purification method Purified by Protein A.
Advisory Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
Type Conjugated Primary Antibody
Cross reactive species Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
Excitation emission 590nm/617nm
Storage Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Target Protein/Peptide MGLUR2/3
Antigen Source KLH conjugated synthetic peptide derived from human MGLUR3
Properties For facs or microscopy Alexa 1 conjugate.
Conjugation Alexa Fluor,ALEXA FLUOR® 594
Conjugated Alexa conjugate 1
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
Gene targetMGLUR2/3
Short name Anti-MGLUR2/3 (Polyclonal)
Technique Polyclonal, anti
Label ALEXA FLUOR 594
Alternative name antibody to-MGLUR2/3 (polyclonal), ALEXA Fluor 594
Alternative technique polyclonals
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