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Alternative_name
(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
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Description
A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
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CAS Number
857064-38-1
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₇H₁₄BrN₃O
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Molecular Weight
356.22
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Cell Permeable
Yes
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Purity
≥97% by HPLC
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Handling
Protect from moisture and air
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Tag Line
A JAK2 inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
12 months
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MDL Number
MFCD12912450
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PubChem CID
11210478
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SMILES
CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
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InChi
InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
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InChi Key
VFUAJMPDXIRPKO-LQELWAHVSA-N
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MSDS Available
Yes