EZSolution™ WP1066

  • Catalog number
    2546-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
  • Description
    A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
  • CAS Number
    857064-38-1
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₇H₁₄BrN₃O
  • Molecular Weight
    356.22
  • Cell Permeable
    Yes
  • Purity
    ≥97% by HPLC
  • Handling
    Protect from moisture and air
  • Tag Line
    A JAK2 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • MDL Number
    MFCD12912450
  • PubChem CID
    11210478
  • SMILES
    CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
  • InChi
    InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
  • InChi Key
    VFUAJMPDXIRPKO-LQELWAHVSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    EZSolution™ WP1066
  • Alternative name
    EZSolution™ WP1066
Similar products
Filters
Contact
Chat with gentaur.com employee