Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)

• Catalog number
  A355320
• Price
  Please ask
• Size
  100 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  In Stock
• Cas number
  314771-76-1
• Chemical s molecular weight
  374.8
• Chemical s main applications
  Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl is a reactant in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
• Chemical s category
  Amines, Aromatics, Chiral Reagents, Heterocycles
• Other name
  N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine; (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine; Des(4-dimethylamino-2-en-1-oxo)butyl Afatinib
• Chemical s formula
  C18H16ClFN4O2
• Physical properties
  Dark Yellow Solid
• Melting temperature
  183-186°C
• Boiling temperature
  No Data Available
• Chemical s soluble in
  DMSO, Methanol
• Stability conditions
  No Data Available
• Storage
  Refrigerator
• Chemical s specifications

• Gene target
  Afatinib-des   4-dimethylamino-2-en-1-oxo   butyl   Contained   Ethanol  
• Gene symbol
  IGHVIII-2-1, MIR1-2, TRUND-NNN9-1, SLC2A4RG, TRH-GTG2-1, MIR511, TRN-ATT1-2, TRG-CCC2-1, TRS-AGA2-1, TRC-GCA2-2
• Short name
  Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8 5% Ethanol)
• Alternative name
  Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)

Gene info

• Identity
  HGNC:5695
• Gene
  IGHVIII-2-1
• Long gene name
  immunoglobulin heavy variable (III)-2-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (III)-2-1
  • immunoglobulin heavy variable (III)-2-1 pseudogene
• Synonyms
  • IGHV(III)-2-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28355
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152321

Gene info

• Identity
  HGNC:31500
• Gene
  MIR1-2
• Long gene name
  microRNA 1-2
• Synonyms gene
  • MIRN1-2
• Synonyms
  • hsa-mir-1-2
• Locus
  18q11.2
• Discovery year
  2004-04-23
• Entrez gene record
  406905
• RefSeq identity
  • NR_029662
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50821
• Gene
  TRUND-NNN9-1
• Long gene name
  tRNA-undetermined (NNN) 9-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 9-1
• GenBank acession
  • HG984098
• Locus
  2
• Discovery year
  2014-06-20
• Entrez gene record
  103482526
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:15930
• Gene
  SLC2A4RG
• Long gene name
  SLC2A4 regulator
• Synonyms
  • GEF
  • HDBP1
  • Si-1-2
  • Si-1-2-19
• Synonyms name
  • GLUT4 enhancer factor
  • Huntington's disease gene regulatory region-binding protein 1
• GenBank acession
  • AF249267
• Locus
  20q13.33
• Discovery year
  2001-06-21
• Entrez gene record
  56731
• Pubmed identfication
  • 10825161
• RefSeq identity
  • NM_020062
• VEGA ID
  OTTHUMG00000032997

Gene info

• Identity
  HGNC:34918
• Gene
  TRH-GTG2-1
• Long gene name
  tRNA-His (GTG) 2-1
• Synonyms gene
  • TRNAH11
• Synonyms gene name
  • transfer RNA histidine 11 (anticodon GUG)
  • transfer RNA-His (GTG) 2-1
• Synonyms
  • tRNA-His-GTG-2-1
• GenBank acession
  • HG983841
• Locus
  1
• Discovery year
  2008-08-29
• Entrez gene record
  100189350
• Classification
  • Low confidence cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:32077
• Gene
  MIR511
• Long gene name
  microRNA 511
• Synonyms gene
  • MIRN511-1
  • MIR511-2
  • MIRN511-2
  • MIR511-1
• Synonyms gene name
  • microRNA 511-2
  • microRNA 511-1
• Synonyms
  • hsa-mir-511-1
  • hsa-mir-511-2
• Locus
  10p12.33
• Discovery year
  2005-07-15
• Entrez gene record
  574445
• RefSeq identity
  • NR_030168
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:50812
• Gene
  TRN-ATT1-2
• Long gene name
  tRNA-Asn (ATT) 1-2
• Synonyms gene name
  • transfer RNA-Asn (ATT) 1-2
• Synonyms
  • tRNA-Asn-ATT-1-2
• GenBank acession
  • HG983628
• Locus
  1q21.1
• Discovery year
  2014-07-07
• Entrez gene record
  103581030
• Classification
  • Low confidence cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34794
• Gene
  TRG-CCC2-1
• Long gene name
  tRNA-Gly (anticodon CCC) 2-1
• Synonyms gene
  • TRNAG22
  • TRG-CCC2-2
• Synonyms gene name
  • transfer RNA glycine 22 (anticodon CCC)
  • transfer RNA-Gly (CCC) 2-2
  • transfer RNA-Gly (CCC) 2-1
• Synonyms
  • tRNA-Gly-CCC-2-1
• GenBank acession
  • HG983799
• Locus
  2p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189231
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34950
• Gene
  TRS-AGA2-1
• Long gene name
  tRNA-Ser (anticodon AGA) 2-1
• Synonyms gene
  • TRNAS25
  • TRS-AGA2-2
• Synonyms gene name
  • transfer RNA serine 25 (anticodon AGA)
  • transfer RNA-Ser (AGA) 2-2
  • transfer RNA-Ser (AGA) 2-1
• Synonyms
  • tRNA-Ser-AGA-2-1
• GenBank acession
  • HG984010
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189382
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34611
• Gene
  TRC-GCA2-2
• Long gene name
  tRNA-Cys (anticodon GCA) 2-2
• Synonyms gene
  • TRNAC5
  • TRC-GCA2-1
• Synonyms gene name
  • transfer RNA cysteine 5 (anticodon GCA)
  • transfer RNA-Cys (GCA) 2-1
  • transfer RNA-Cys (GCA) 2-2
• Synonyms
  • tRNA-Cys-GCA-2-2
• GenBank acession
  • HG983686
• Locus
  17q12
• Discovery year
  2008-08-29
• Entrez gene record
  100189052
• Classification
  • Cytoplasmic transfer RNAs

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