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Otoraplin OTOR human recombinant

Otoraplin OTOR human recombinant is available 2 times from Biovision labs

4987-20 | Otoraplin (OTOR), human recombinant size: 20 ug | 329.02 USD

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4987-1000 | Otoraplin (OTOR), human recombinant size: 1 mg | 6,397.85 USD

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Synonyms Otoraplin, Fibrocyte-derived protein, Melanoma inhibitory activity-like protein, OTOR, MIAL, FDP, MIAL1, MGC126737, MGC126739,
Alternative_names Otoraplin, Fibrocyte-derived protein, Melanoma inhibitory activity-like protein, OTOR, MIAL, FDP, MIAL1, MGC126737, MGC126739,
Description Functions in cartilgae development and maintainence
Recombinant Yes
Source E. coli
Purity by SDS-PAGE ≥98%
Assay SDS-PAGE
Purity ≥98%
Biological activity Not available at this time
Molecular Weight 12.7 kDa
Storage Temp. -20°C
Shipping Blue ice
Shelf Life 12 months
Appearance Lyophilized protein
Physical form description Sterile filtered and lyophilized from a concentrated (1 mg/ml) solution containing 20 mM PBS pH-7.4 and 130 mM NaCl.
Reconstitution Instructions Reconstitute in sterile dH₂O to a concentration of 0.1 -1 mg/ml. This solution can then be diluted into other aqueous buffers
Background Information TOR proteins is also known as fibrocyte-derived protein (Fdp) and Melanoma inhibitory activity-like (MIAL). Otoraplin is a member of the melanoma-inhibiting activity gene family. Otoraplin is a secreted 16 kDa globular protein that is expressed in the inner ear by periotic mesenchyme and developing and mature fibrocytes. OTOR is highly homologous to MIA/cartilage-derived retinoic acid-sensitive protein (CD-RAP), which is a cartilage-specific protein that is also expressed in malignant melanoma cells. The 111 amino acid mature human otoraplin contains 1 SH3 domain (46 –107 amino acids) and a Tyr at position 50 that is reportedly sulfated. Otoraplin takes part in the initiation of periotic mesenchyme chondrogenesis. Otoraplin is secreted through the Golgi apparatus and plays a role in cartilage development and maintenance. A frequent polymorphism in the translation start codon of OTOR can abolish translation and may be associated with forms of deafness. Recombinant human Otoraplin produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids and having a molecular mass of 12.7 kDa.The OTOR is purified by proprietary chromatographic techniques.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetOtoraplin OTOR
Short name Otoraplin (OTOR) recombinant
Technique Recombinant
Species Human
Alternative name Otoraplin (OTOR), H. sapiens recombinant
Alternative technique rec
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