Elastase, Human Neutrophil

• Catalog number
  4716-100
• Price
  Please ask
• Size
  100 µg

• Synonyms
  Leukocyte Elastase, ELA2
• Alternative_names
  Leukocyte Elastase, ELA2
• Description
  Breaks down elastin
• Recombinant
  No
• Source
  Human Neutrophil
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Activity Specifications test method
  20-22 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Meo-Suc-Ala-Pro-Val-pNA per minute at 25°C in 100 mM Tris-HCl, pH 7.5, with 500 mM NaCl.
• Molecular Weight
  29.5 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Salt- free lyophilized solid
• Reconstitution Instructions
  Deionized H₂O
• Background Information
  Elastase, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. Elastase is distinctive in that it acts upon elastin.This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

• Gene target
  Elastase   Neutrophil  
• Gene symbol
  ELANE, SERPINB1
• Short name
  Elastase, Neutrophil
• Species
  Human, Humans
• Alternative name
  Elastase, H. sapiens Neutrophil

Gene info

• Identity
  HGNC:3309
• Gene
  ELANE
• Long gene name
  elastase, neutrophil expressed
• Synonyms gene
  • ELA2
• Synonyms gene name
  • elastase 2, neutrophil
• Synonyms
  • NE
  • HNE
  • HLE
  • PMN-E
• Synonyms name
  • neutrophil elastase
  • leukocyte elastase
  • medullasin
  • PMN Elastase
  • polymorphonuclear leukocyte elastase
• Locus
  19p13.3
• Discovery year
  1989-09-08
• Entrez gene record
  1991
• Pubmed identfication
  • 2902087
• RefSeq identity
  • NM_001972
• Classification
  • Granule associated serine proteases of immune defence
  • Complement system regulators and receptors
• VEGA ID
  OTTHUMG00000181839
• Locus Specific Databases
  • ELA2base: Mutation registry for Cyclic and congenital neutropenia
  • LRG_57

Gene info

• Identity
  HGNC:3311
• Gene
  SERPINB1
• Long gene name
  serpin family B member 1
• Synonyms gene
  • ELANH2
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1
  • serpin peptidase inhibitor, clade B (ovalbumin), member 1
• Synonyms
  • EI
  • PI2
  • LEI
  • MNEI
• Synonyms name
  • leukocyte elastase inhibitor
  • monocyte/neutrophil elastase inhibitor
  • anti-elastase
• GenBank acession
  • M93056
• Locus
  6p25.2
• Discovery year
  1993-07-27
• Entrez gene record
  1992
• Pubmed identfication
  • 1376927
  • 24172014
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000014124

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