IL18BP, human recombinant

• Catalog number
  7324-100
• Price
  Please ask
• Size
  100 ug

• Synonyms
  Interleukin-18-binding protein, IL18BPa
• Alternative_names
  Interleukin-18-binding protein, IL18BPa
• Description
  An inhibitor of the proinflammatory cytokine, IL18
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1.0 EU per 1 microgram of protein
• Molecular Weight
  20 kDa (187 aa, 31-194 aa + His Tag), confirmed by MALDI-TOF.
• Storage Temp
  -80°C
• Shipping
  Dry Ice
• Shelf Life
  12 months
• Concentration
  1 mg/ml
• Appearance
  Liquid
• Physical form description
  1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
• Background Information
  IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL18BP  
• Gene symbol
  IL18BP
• Short name
  IL18BP, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  interleukin 18 binding protein, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  interleukin 18 binding protein, IL18BPa, IL18BP and IDBG-62960 and ENSG00000137496 and 10068, receptor anta this GO nist activity, Extracellular, Il18bp and IDBG-202395 and ENSMUSG00000070427 and 16068, IL18BP and IDBG-634897 and ENSBTAG00000027676 and 617470

Gene info

• Identity
  HGNC:5987
• Gene
  IL18BP
• Long gene name
  interleukin 18 binding protein
• Synonyms
  • IL18BPa
• Synonyms name
  • MC51L-53L-54L homolog gene product
• GenBank acession
  • AF110798
• Locus
  11q13.4
• Discovery year
  1999-05-21
• Entrez gene record
  10068
• Pubmed identfication
  • 10023777
• RefSeq identity
  • NM_173042
• Classification
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000133713

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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