anti-Beclin 2 Antibody
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Catalog number7989
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3). Like Beclin 1, Beclin 2 interacts with Bcl-2 and class III PI3K complex components. However, Beclin 2 functions in an additional lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3). Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells, suggesting that it may also play a role in regulating other intracellular signaling pathways (4).
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Gene namesBECN2, BECN1L1, Beclin-1-like protein 1, Beclin 1 autophagy related pseudogene 1, BECN1P1
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Antibodie s labelunlabelled serum
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PurityBeclin 2 antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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Spicific toBeclin 2 antibody is human specific. At least two isoforms of Beclin 2 are known to exist; this antibody will only detect the longer isoform. Beclin 2 antibody is predicted to not cross-react with Beclin 1.
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AntigenBeclin 2 antibody was made against a 16 amino acid peptide near the amino terminus of human Beclin 2.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody adviceBeclin 2 antibody can be used for detection of Beclin 2 by Western blot at 1 - 2 ug/ml. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azideBeclin 2 antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atBeclin 2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
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Works withHuman
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Omim nr595582373
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Ncbi nrNP_001277622
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KDaPredicted: 47 kDa Observed: 55 kDa
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr441925
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GENE symbolBECN1P1
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Antigene namebeclin 1, autophagy related, pseudogene 1
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Sourcehomo sapiens
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Protein nrA8MW95
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolBECN2, BECN1P2
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Short nameanti-Beclin 2 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toBeclin 2 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namebeclin 2
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Synonyms gene
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Synonyms gene name
- beclin 1, autophagy related, pseudogene 1
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Locus
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Discovery year2010-06-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namebeclin 1 pseudogene 2
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Synonyms gene name
- beclin 1, autophagy related, pseudogene 2
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Locus
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Discovery year2014-10-03
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Entrez gene record
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data