anti-Beclin 2 Antibody

  • Catalog number
    7989
  • Price
    Please ask
  • Size
    0.02 mg, 0.1 mg
  • Gene info
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3). Like Beclin 1, Beclin 2 interacts with Bcl-2 and class III PI3K complex components. However, Beclin 2 functions in an additional lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3). Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells, suggesting that it may also play a role in regulating other intracellular signaling pathways (4).
  • Gene names
    BECN2, BECN1L1, Beclin-1-like protein 1, Beclin 1 autophagy related pseudogene 1, BECN1P1
  • Antibodie s label
    unlabelled serum
  • Purity
    Beclin 2 antibody is affinity chromatography purified via peptide column.
  • Ab raised in
    Rabbit
  • Type
    Polyclonal
  • Immunoglobulin
    IgG
  • Spicific to
    Beclin 2 antibody is human specific. At least two isoforms of Beclin 2 are known to exist; this antibody will only detect the longer isoform. Beclin 2 antibody is predicted to not cross-react with Beclin 1.
  • Antigen
    Beclin 2 antibody was made against a 16 amino acid peptide near the amino terminus of human Beclin 2.
  • Immuno application
    ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
  • Antibody advice
    Beclin 2 antibody can be used for detection of Beclin 2 by Western blot at 1 - 2 ug/ml. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
  • Suspention pH azide
    Beclin 2 antibody is supplied in PBS containing 0.02% sodium azide.
  • Keep at
    Beclin 2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
  • Works with
    Human
  • Omim nr
    595582373
  • Ncbi nr
    NP_001277622
  • KDa
    Predicted: 47 kDa Observed: 55 kDa
  • Vial with antibody
    in solution
  • Quantity per ml
    1 mg/mL
  • NCBI GENE nr
    441925
  • GENE symbol
    BECN1P1
  • Antigene name
    beclin 1, autophagy related, pseudogene 1
  • Source
    homo sapiens
  • Protein nr
    A8MW95
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    Beclin  
  • Gene symbol
    BECN2, BECN1P2
  • Short name
    anti-Beclin 2 Antibody
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toBeclin 2 (antibody to-)
  • Alternative technique
    antibodies
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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