anti-JNK1 / JNK2 (phospho Thr183 / Tyr185) Antibody
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Catalog number79-504
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PricePlease ask
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Size0.1 mg
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Gene infoResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it./Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity
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Gene namesJNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2, FLT, FRT, VEGFR1, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1
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Antibodie s labelunlabelled serum
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PurityAntibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
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Ab raised inRabbit
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TypePolyclonal
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Spicific toThis antibody detects endogenous level of JNK1/JNK2 only when phosphorylated at Thr183/Tyr185.
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AntigenJNK1/JNK2 (phospho-Thr183/Tyr185) antibody was made against a peptide sequence around phosphorylation site of Thr183/Tyr185 (M-M-T (p) -P-Y (p) - V - V ) derived from Human JNK1/JNK2.
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Immuno applicationWestern Blot, immuno fluorescence
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Antibody adviceWestern Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
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Suspention pH azideAntibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Keep atStore antibody at -20 grades C for up to one year.
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Works withHuman, Mouse, Rat
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Omim nr4506095 / 205277412 / 4506081
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Ncbi nrNP_002741.1 / NP_001128516.1 / NP_002744.1
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KDa46, 54 kDa
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr5599 / 5601 / 5602
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GENE symbolMAPK8 MAPK9 MAPK10
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Antigene namemitogen-activated protein kinase 8 / mitogen-activated protein kinase 9 / mitogen-activated protein kinase 10
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SourceHomo sapiens
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Protein nrP45983 P45984 P53779
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolMAPK8, MAPK9
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Short nameanti-JNK1 / JNK2 (phospho Thr183 / Tyr185) Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toJNK1 / JNK2 (phosphorilated Thr183 / Tyr185) (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 8
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-04-28
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Entrez gene record
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Pubmed identfication
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Classification
- Mitogen-activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 9
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-04-28
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Entrez gene record
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Pubmed identfication
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Classification
- Mitogen-activated protein kinases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data