GN25

• Catalog number
  9430-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3-​[(1,​4-​dihydro-​5,​8-​dimethoxy-​1,​4-​dioxo-​2-​naphthalenyl)thio]-​propanoic acid
• Description
  GN25 blocks Snail binding to p53 and induces p53 expression in cancer cells in a KRas dependent manner. Oncogenic KRas has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. At 10 μM, GN25 significantly reduces cell proliferation in KRas mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.
• CAS Number
  1227401-27-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₁₄O₆S
• Molecular Weight
  322.3
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (~5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A p53-Snail-binding inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• SMILES
  O=C(O)CCSC(C1=O)=CC(C2=C1C(OC)=CC=C2OC)=O
• InChi
  InChI=1S/C15H14O6S/c1-20-9-3-4-10(21-2)14-13(9)8(16)7-11(15(14)19)22-6-5-12(17)18/h3-4,7H,5-6H2,1-2H3,(H,17,18)
• InChi Key
  DIIRLGMLDOPLPV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GN25  
• Short name
  GN25
• Alternative name
  GN25

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