AMI-5
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Catalog number2300-250
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PricePlease ask
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Size250 mg
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Alternative_name2′,4′,5′,7′-Tetrabromofluorescein disodium salt, Acid Red 87, Bromo acid J. TS, XL, or XX, Bromofluorescein, Bronze Bromo ES, Eosin yellowish
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DescriptionAMI-5 is a non-specific small molecule inhibitor of protein arginine methyltransferases (PRMTs) (IC₅₀ = 0.78 and 1.41 µM against Hmt1p and PRMT1, respectively) and histone lysine methyltransferases (HKMTs) (DOT1 and SET7, but not Suv39H1 and Suv39H2).
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CAS Number17372-87-1
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Structure AvailableYes
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Peptide sequenceNo
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Salt FormNo
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Molecular FormulaC₂₀H₆Br₄Na₂O₅
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Molecular Weight691.85
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Cell PermeableNo
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Purity≥90% (based on the anhydrous material)
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SolubilitiesH2O (1 mg/ml)
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HandlingProtect from air and light
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Tag LineA protein methyltransferase inhibitor
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Storage Condition+4 ÌŠC
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Shipping Conditiongel pack
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Shelf Life60 months
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MDL NumberMCFD00005040
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PubChem CID11048
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SMILESC1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]
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InChiInChI=1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
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InChi KeySEACYXSIPDVVMV-UHFFFAOYSA-L
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MSDS AvailableYes
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Gene target
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Gene symbolMIR1302-5, PIRC23, PIRC22, PIRC20, PIRC21, HTR6, IGHV2OR16-5, IGKV3OR2-5, SNORD116-5, TGFB1I1
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Short nameAMI-5
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Alternative nameAMI-5
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Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-5
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 23
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 22
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 20
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 21
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene name5-hydroxytryptamine receptor 6
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Synonyms gene name
- 5-hydroxytryptamine (serotonin) receptor 6
- 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-12-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- 5-hydroxytryptamine receptors, G protein-coupled
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 2/OR16-5 (non-functional)
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Synonyms gene name
- immunoglobulin heavy variable 2/OR16-5
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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Classification
- Immunoglobulin heavy (IGH) orphons
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 3/OR2-5 (pseudogene)
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Synonyms gene name
- immunoglobulin kappa variable 3/OR2-5
- immunoglobulin kappa variable 3/OR2-5 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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Classification
- Immunoglobulin kappa (IGK) orphons
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 116-5
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nametransforming growth factor beta 1 induced transcript 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-03-23
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Entrez gene record
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Pubmed identfication
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Classification
- LIM domain containing
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VEGA ID