Human Recombinant PIN4

• Catalog number
  6387-100
• Price
  Please ask
• Size
  100 ug

• Synonyms
  Human Recombinant PIN4
• Alternative_names
  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2, Parvulin-14, Parvulin-17, PPIase Pin4, hEPVH, PAR14, PAR17
• Description
  Vital for cell cycle regulation
• Recombinant
  Yes
• Source
  E. Coli
• Purity by SDS PAGE
  ≥85%
• Assay
  SDS-PAGE
• Biological activity
  Specific activity is > 300 nmoles/min/mg
• Results
  >300 nmoles/min/mg
• Unit Definition
  One unit is defined as the amount of enzyme that cleaves 1 µmole of Suc-AAFP-pNA per minute at 25°C in Tris HCl pH 8.0 using chymotrypsin.
• Molecular Weight
  18.8 kDa (176 aa, 1-156 aa + NT His Tag)
• Storage Temp
  -20°C
• Shipping
  gel pack
• Shelf Life
  12 months
• Concentration
  1 mg/ml
• Appearance
  Liquid
• Physical form description
  1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 mM PMSF, 1 mM DTT and 10% glycerol.
• Background Information
  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4) is a peptidyl-prolyl cis/trans isomerase (PPIase) which interacts with NIMA and is vital for cell cycle regulation. PIN4 has 2 different isoforms: PAR14 and PAR17. Furthermore, Pin4 protein binds to double-stranded DNA under physiological salt conditions.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MPMAGLLKGL VRQLERFSVQ QQASKMPPKG KSGSGKAGKG GAASGSDSAD KKAQGPKGGG NAVKVRHILC EKHGKIMEAM EKLKSGMRFN EVAAQYSEDK ARQGGDLGWM TRGSMVGPFQ EAAFALPVSG MDKPVFTDPP VKTKFGYHII MVEGRK
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  PIN4  
• Gene symbol
  PIN4
• Short name
  Recombinant PIN4
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  H. sapiens Rec. PIN4
• Alternative technique
  rec

Gene info

• Identity
  HGNC:8992
• Gene
  PIN4
• Long gene name
  peptidylprolyl cis/trans isomerase, NIMA-interacting 4
• Synonyms gene name
  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
  • peptidylprolyl cis/trans isomerase NIMA-interacting, 4
• Synonyms
  • PAR14
  • PAR17
  • EPVH
• Synonyms name
  • parvulin
• GenBank acession
  • AB009690
• Locus
  Xq13.1
• Discovery year
  1998-08-26
• Entrez gene record
  5303
• Pubmed identfication
  • 16522211
  • 17875217
• RefSeq identity
  • NM_006223
• Classification
  • Parvulins
• VEGA ID
  OTTHUMG00000021811
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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