TAB1(Thr431) Antibody, ALEXA FLUOR 647

• Catalog number
  bs-5496R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  TAB1(Thr431) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-TAB1 Thr431 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  TAB1 Thr431
• Specificity
  This is a highly specific antibody against TAB1 Thr431.
• Modification
  Phosphorylation
• Modification Site
  Thr431
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human TAB1 around the phosphorylation site of Ser431
• Gene ID Number
  10454
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  MAP3K7IP1phospho S431; MAP3K7IP 1; MAP3K7IP1; Mitogen activated protein kinase kinase kinase 7 interacting protein 1; TAB 1; TAK1 binding protein 1; TGF beta activated kinase 1 binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; Transforming growth factor beta activated kinase binding protein 1; 2310012M03Rik; 3'-Tab1; MGC57664; TAB1_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-TAB1 Thr431 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  TAB1   Thr431  
• Gene symbol
  TAB1
• Short name
  Anti-TAB1 Thr431
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  TAB1(Thr431) Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies
• Alternative to gene target
  TGF-beta activated kinase 1/MAP3K7 binding protein 1, 3\'-Tab1 and MAP3K7IP1, TAB1 and IDBG-8281 and ENSG00000100324 and 10454, mitogen-activated protein kinase p38 binding, nuclei, Tab1 and IDBG-163423 and ENSMUSG00000022414 and 66513, MAP3K7IP1 and IDBG-641725 and ENSBTAG00000019828 and 519958

Gene info

• Identity
  HGNC:18157
• Gene
  TAB1
• Long gene name
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
• Synonyms gene
  • MAP3K7IP1
• Synonyms gene name
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 1
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1
• Synonyms name
  • TAK1-binding protein 1
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 1
• GenBank acession
  • U49928
• Locus
  22q13.1
• Discovery year
  2002-02-22
• Entrez gene record
  10454
• Pubmed identfication
  • 8638164
  • 10187861
• RefSeq identity
  • NM_153497
• VEGA ID
  OTTHUMG00000151102

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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