DICER1 - Blocking Peptide

• Catalog number
  X2771B
• Price
  Please ask
• Size
  50 μg

• Category
  Proteins & Peptides
• Long description
  This peptide is the immunogen used to make Cat # X2756P. _x000B__x000B_Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
• Antibody come from
  Synthetic peptide derived from the human SALL4 protein
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide.
• Clone
  not specified
• Antigen antibody binding interaction
  DICER1 - Blocking Peptide
• Antibody is raised in
  see techfile
• Antibody s reacts with
  Blocking Peptide to Cat # X2756P
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Blocking Peptide
• Antibody s suited for
  Antibody can be used for Immunohistochemistry (2-4 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Ma, Y., et al. ÔSALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.Õ Blood, 108, 2726-2735 (2006)_x000B_2. Kohlhase, J., et al. ÔOkihiro syndrome is caused by SALL4 mutations.Õ Hum. Mol. Genet., 11, 2979-2987 (2002)_x000B_3. Yang, F., et al. ÔSumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.Õ J. Biol. Chem., 287, 38600-38608 (2012)
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Test
  You can block the antibody by the specific target amino acid sequence of peptide.
• Properties
  blocking peptide
• Description
  Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.

• Gene target
  DICER1  
• Gene symbol
  DICER1-AS1, DICER1
• Short name
  DICER1 - Blocking Peptide
• Technique
  blocking peptide, Blocking, peptide, blocking peptides, nordc made this blocking amino acid sequence or peptide to block the gene target in a volume of 1. For western blot it is often requested to block your antibody and to see the band of the analyzed protein disappear. This is called a negative control by blocking the WB antibody. peptides
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  DICER1 - inhibiting short protein sequence
• Alternative technique
  control, peptides

Gene info

• Identity
  HGNC:43017
• Gene
  DICER1-AS1
• Long gene name
  DICER1 antisense RNA 1
• Synonyms gene
  • DICER1-AS
• Synonyms gene name
  • DICER1 antisense RNA (non-protein coding)
• Synonyms
  • FLJ45244
• Synonyms name
  • DICER1 antisense RNA (non-protein coding)
• GenBank acession
  • BC040596
• Locus
  14q32.13
• Discovery year
  2011-09-16
• Entrez gene record
  400242
• Pubmed identfication
  • 29772430
• RefSeq identity
  • NR_015415
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000150190

Gene info

• Identity
  HGNC:17098
• Gene
  DICER1
• Long gene name
  dicer 1, ribonuclease III
• Synonyms gene
  • MNG1
• Synonyms gene name
  • Dicer1, Dcr-1 homolog (Drosophila)
  • multinodular goitre 1
  • dicer 1, ribonuclease type III
• Synonyms
  • Dicer
  • KIAA0928
  • K12H4.8-LIKE
  • HERNA
• Synonyms name
  • dicer 1, double-stranded RNA-specific endoribonuclease
• GenBank acession
  • AB028449
• Locus
  14q32.13
• Discovery year
  2002-05-09
• Entrez gene record
  23405
• Pubmed identfication
  • 10051563
  • 10786632
  • 21205968
• RefSeq identity
  • NM_030621
• Classification
  • RISC loading complex
  • Endoribonucleases
  • RNA helicases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000166134
• Locus Specific Databases
  • LRG_492

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