DICER1 - Blocking Peptide
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Catalog numberX2771B
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PricePlease ask
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Size50 μg
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CategoryProteins & Peptides
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Long descriptionThis peptide is the immunogen used to make Cat # X2756P. _x000B__x000B_Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
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Antibody come fromSynthetic peptide derived from the human SALL4 protein
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide.
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Clonenot specified
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Antigen antibody binding interactionDICER1 - Blocking Peptide
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Antibody is raised insee techfile
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Antibody s reacts withBlocking Peptide to Cat # X2756P
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationBlocking Peptide
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Antibody s suited forAntibody can be used for Immunohistochemistry (2-4 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.
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Storage-20ºC
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Relevant references1. Ma, Y., et al. ÔSALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.Õ Blood, 108, 2726-2735 (2006)_x000B_2. Kohlhase, J., et al. ÔOkihiro syndrome is caused by SALL4 mutations.Õ Hum. Mol. Genet., 11, 2979-2987 (2002)_x000B_3. Yang, F., et al. ÔSumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.Õ J. Biol. Chem., 287, 38600-38608 (2012)
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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TestYou can block the antibody by the specific target amino acid sequence of peptide.
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Propertiesblocking peptide
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DescriptionPeptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.
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Gene target
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Gene symbolDICER1-AS1, DICER1
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Short nameDICER1 - Blocking Peptide
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Techniqueblocking peptide, Blocking, peptide, blocking peptides, nordc made this blocking amino acid sequence or peptide to block the gene target in a volume of 1. For western blot it is often requested to block your antibody and to see the band of the analyzed protein disappear. This is called a negative control by blocking the WB antibody. peptides
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Isotypenot specified
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Labelunlabeled
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Alternative nameDICER1 - inhibiting short protein sequence
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Alternative techniquecontrol, peptides
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Gene info
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Identity
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Gene
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Long gene nameDICER1 antisense RNA 1
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Synonyms gene
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Synonyms gene name
- DICER1 antisense RNA (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2011-09-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namedicer 1, ribonuclease III
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Synonyms gene
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Synonyms gene name
- Dicer1, Dcr-1 homolog (Drosophila)
- multinodular goitre 1
- dicer 1, ribonuclease type III
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-05-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RISC loading complex
- Endoribonucleases
- RNA helicases
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases