Proteins & Peptides
Antibody is raised in
Antibody's reacts with
Blocking Peptide to Cat # X2756P
Antibody's suited for
Antibody can be used for Immunohistochemistry (2-4 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Antigen-antibody binding interaction
DICER1 - Blocking Peptide
Antibody come from
Synthetic peptide derived from the human SALL4 protein
Provided as solution in phosphate buffered saline with 0.08% sodium azide.
This peptide is the immunogen used to make Cat # X2756P. _x000B__x000B_Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
Antibody's reacts with these species
This antibody doesn't cross react with other species
1. Ma, Y., et al. ÔSALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.Õ Blood, 108, 2726-2735 (2006)_x000B_2. Kohlhase, J., et al. ÔOkihiro syndrome is caused by SALL4 mutations.Õ Hum. Mol. Genet., 11, 2979-2987 (2002)_x000B_3. Yang, F., et al. ÔSumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.Õ J. Biol. Chem., 287, 38600-38608 (2012)
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
No Data Available
You can block the antibody by the specific target amino acid sequence of peptide.
Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.