Description
VU 0361737 is a selective, brain-permeable, positive allosteric modulator at mGlu4 receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.
Peptide sequence
N/A
CAS number
1161205-04-4
Molecular weight
262.69
Category
Biochemicals
Other name
N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Molecular formula
C₁₃H₁₁ClN₂O₂
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Additional description
For cells, cell lines and tissues in culture till half confluency.
Gene targetVU0361737
for
activation
Short name
VU0361737 for activation
Technique
activation
Alternative name
VU0361737 to measure cellular activation
Tissue
cell
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