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Human Recombinant FKBP3

Human Recombinant FKBP3 is available 1 time from Biovision labs

6342-100 | Human Recombinant FKBP3 size: 100 ug | 460.51 USD

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Synonyms Human Recombinant FKBP3
Alternative_names FK506 binding protein 3, FKBP25, PPIase FKBP3, Rotamase
Description An immunophilin family protein functioning as a protein folding chaperone
Recombinant Yes
Source E. Coli
Purity by SDS-PAGE ≥90%
Assay SDS-PAGE
Biological activity Specific activity is > 490 nmoles/min/mg.
Unit Definition Specific activity is > 490 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 µmole of suc-AAFP-pNA per minute at 25°C in Tris HCl pH 8.0 using chymotrypsin.
Molecular Weight 25.1 kDa
Storage Temp. -20°C
Shipping gel pack
Shelf Life 12 months
Concentration 1 mg/ml
Appearance Liquid
Physical form description 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
Background Information FKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin.
Amino acid sequence MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetFKBP3
Short name Recombinant FKBP3
Technique Recombinant
Species Human
Alternative name H. sapiens recombinant FK506 binding protein 3, 25kDa
Alternative technique rec
Alternative to gene target FK506 binding protein 3, 25kDa, FKBP-25 and FKBP-3 and FKBP25 and PPIase, FKBP3 and IDBG-5577 and ENSG00000100442 and 2287, poly(A) RNA binding, nuclei, Fkbp3 and IDBG-143170 and ENSMUSG00000020949 and 30795, FKBP3 and IDBG-633002 and ENSBTAG00000002610 and 515069
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