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Target antigen
CD79a
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
Human. No cross reactivity with other proteins.
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Analyses
WB,IHC-P,ICC
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Immunogen
E.coli-derived human CD79a recombinant protein (Position: T121-P226). Human CD79a shares 91% amino acid (aa) sequence identity with mouse CD79a.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the CD79a Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The CD79a Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene. It is mapped to 19q13.2. CD79A is a membrane protein with an extracellular immunoglobulin domain, a single span transmembrane region and a short cytoplasmic domain. Genetic deletion of the transmembrane exon of CD79A results in loss of CD79A protein and a complete block of B cell development at the pro to pre B cell transition. Similarly, humans with homozygous splice variants in CD79A predicted to result in loss of the transmembrane region and a truncated or absent protein display agammaglobulinemia and no peripheral B cells.
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Related articles
1. Pelanda R, Braun U, Hobeika E, Nussenzweig MC, Reth M (2002). "B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta". J. Immunol. 169 (2): 865–72. 2. Minegishi Y, Coustan-Smith E, Rapalus L, Ersoy F, Campana D, Conley ME (1999). "Mutations in Igalpha (CD79a) result in a complete block in B-cell development.". The Journal of Clinical Investigation 104 (8): 1115–21. 3. Wang Y, Kanegane H, Sanal O, Tezcan I, Ersoy F, Futatani T, Miyawaki T (2002). "Novel Ig a (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia". American Journal of Medical Genetics 336: 333–336.
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Gene Name
CD79A
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Protein Name
B-cell antigen receptor complex-associated protein alpha chain
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Gene Full Name
CD79a molecule, immunoglobulin-associated alpha
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Synonyms
B cell antigen receptor complex associated protein alpha chain antibody|B cell antigen receptor complex associated protein alpha chain precursor antibody|B Lymphocyte Specific MB1 Protein antibody|B lymphocyte-specific MB1 protein antibody|B-cell antigen receptor complex-associated protein alpha chain antibody|CD 79a antibody|CD79a antibody|CD79a antigen (immunoglobulin-associated alpha) antibody|CD79A antigen antibody|CD79A antigen immunoglobulin associated alpha antibody|CD79a molecule immunoglobulin associated alpha antibody|CD79a molecule, immunoglobulin-associated alpha antibody|CD79A_HUMAN antibody|Ig alpha antibody|Ig-alpha antibody|IGA antibody|IgM-alpha antibody|Immunoglobulin Associated Alpha antibody|Immunoglobulin-associated alpha antibody|Ly54 antibody|MB 1 antibody|MB 1 membrane glycoprotein antibody|MB-1 membrane glycoprotein antibody|MB1 antibody|MB1 membrane glycoprotein antibody|Membrane bound immunoglobulin associated protein antibody|Membrane-bound immunoglobulin-associated protein antibody|Surface IgM associated protein antibody|Surface IgM-associated protein antibody
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Uniprot ID
P11912
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Entrez GeneID
973
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
