Activin A Recombinant Protein

  • Catalog number
    40-212
  • Price
    Please ask
  • Size
    0.002 mg, 0.01 mg
  • About recombinant protein
    Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, Follistatin. Human Activin A is a 26.0 kDa disulfide-linked homodimer of two β A chains, each containing 116 amino acid residues.
  • Other name of the recombinant
    JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2
  • Recombinant in
    (BTI-Tn-5B1-4) High-5 Insect cells
  • SEQUENCE
    GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
  • Activity
    The ED50 was determined by its ability to inhibit the proliferation of murine MPC - 11 cells is ≤ 2 ng/mL, corresponding to a specific activity of ≥ 5 x 105 units/mg.
  • Keep at
    The lyophilized Activin A recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Activin A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Activin A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec PROTEIN GI
    51173730
  • Accession nr
    NP_001003652.1
  • Pureity
    Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
  • About
    This product is for research use only.
  • Protein s origin
    Human
  • Vial
    Lyophilized
  • NCBI ID
    4087
  • Gene name
    SMAD family member 2
  • Source
    Homo sapiens
  • Uniprot
    Q15796
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    SMAD2
  • Short name
    Activin A Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    Activin A Rec. Protein
  • Alternative technique
    rec
Gene info
  • Identity
  • Gene
  • Long gene name
    SMAD family member 2
  • Synonyms gene
  • Synonyms gene name
    • MAD, mothers against decapentaplegic homolog 2 (Drosophila)
    • SMAD, mothers against DPP homolog 2 (Drosophila)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1996-11-15
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • SMAD family
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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