SB202190, p38 MAP kinase inhibitor
-
Catalog numberSIH-473-25MG
-
PricePlease ask
-
Size25 mg
-
-
Stock availabilitIn StockIn Stock
-
CAS number152121-30-7
-
Descriptionp38 MAP kinase inhibitor
-
Molecular weight331,3 g/mol
-
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
-
Other nameFHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
-
Product categorySmall Molecules
-
Product typeInhibitor
-
Chemical formulaC20H14FN3O
-
OriginSynthetic
-
Purity pourcentage≥98% (TLC)
-
Soluble inSoluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate
-
Physical appearancePale yellow solid
-
Storage recommendations-20ºC
-
Shipping recommendationsShipped Ambient
-
Safety informationClassification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instru ctions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant
-
PubChem number5353940
-
Scientific contextSB202190 is a highly selective and potent inhibitor of p38 MAP kinase. Specifically, it binds within the ATP pocket of the active kinase and selectively inhibits the p38α and β isoforms. It has been shown to induce apoptosis. SB202190 is cell-permeable.
-
Bibliography1. Nemoto S., Xiang J., Huang S., & Lin A. (1998) J. Bio. Chem. 273(26): 16415–16420. 2. Karahashi H., Nagata K., Ishii K., & Amano F. (2000) Biochimica Et Biophysica Acta. 1502(2): 207–223.
-
Release date1-Oct-2014
-
PubMed numberRefer to PubMed
-
Tested applicationsTo be tested
-
Tested reactivityTo be tested
-
Representative figure legendChemical structure of SB202190 (SIH-473), a p38 MAP kinase inhibitor. CAS #: 152121-30-7. Molecular Formula: C20H14FN3O. Molecular Weight: 331.3 g/mol. Chemical structure of SB202190, a p38 MAP kinase inhibitor (SIH-473). CAS # 152121-30-7. Molecular Formula: C20H14FN3O.
-
Warning informationNon-hazardous
-
Country of productionCanada
-
Total weight kg0.25
-
Net weight g0.025
-
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbolMOAP1, MAP7, MASP2, MASP1
-
Short nameSB202190, p38 MAP kinase inhibitor
-
Alternative nameSB202190, p38 mitogen-stimulated protein kinase phosphorylation catalyst suppressor
-
Gene info
-
Identity
-
Gene
-
Long gene namemodulator of apoptosis 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-11-13
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Paraneoplastic Ma antigens
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemicrotubule associated protein 7
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1999-01-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameMBL associated serine protease 2
-
Synonyms gene
-
Synonyms gene name
- mannan-binding lectin serine protease 2
- mannan-binding lectin serine peptidase 1 pseudogene 1
- mannan-binding lectin serine protease 1 pseudogene 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1998-12-17
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Sushi domain containing
- Complement system activation components
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameMBL associated serine protease 1
-
Synonyms gene
-
Synonyms gene name
- mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)
- mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
- mannan binding lectin serine peptidase 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1995-07-06
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Serine proteases
- Complement system activation components
- Sushi domain containing
-
VEGA ID
-
Locus Specific Databases
