RANK, Ectodomain (Receptor Activator of NFkB)[RANK, Ectodomain]

  • Catalog number
    MBS611176
  • Price
    Please ask
  • Size
    NA
  • Products_type
    Antibody
  • Reactivity
    Human
  • Gene
    NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
  • Description
    The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Gene target
  • Gene symbol
    ANKFY1, TNFRSF11A
  • Short name
    RANK, Ectodomain (Receptor Activator of NFkB)[RANK, Ectodomain]
  • Host
    Rabbit
  • Alternative name
    RANK, Ectodomain (Receptor Activator on NFkB)[RANK, Ectodomain]
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