SU 16f
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Catalog numberB1081-25
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PricePlease ask
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Size25 mg
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Alternative_name5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
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DescriptionSU 16f is a potent, cell-permeable and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC₅₀ = 10 nM). It displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC₅₀ = 0.11 μM).
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CAS Number251356-45-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₂₂N₂O₃
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Molecular Weight386.44
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>35 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent, cell-permeable and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD03452699
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PubChem CID5329150
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SMILESCC1=C(NC(=C1CCC(=O)O)C)C=C2C3=C(C=C(C=C3)C4=CC=CC=C4)NC2=O
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InChinChI=1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13-
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InChi KeyAPYYTEJNOZQZNA-MOSHPQCFSA-N
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MSDS AvailableYes
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Gene target
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Short nameSU 16f
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Alternative nameSU 16f
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