Rocaglamide
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Catalog number1863-100
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PricePlease ask
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Size100 ug
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Alternative_nameRocaglamide A
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DescriptionAn immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.
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CAS Number84573-16-0
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₉H₃₁NO₇
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Molecular Weight505.56
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO or EtOH
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HandlingProtect from air and light
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Tag LineAn immunosuppressant
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD08702699
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PubChem CID331783
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SMILESCN(C)C(=O)C1C(C2(C(C1O)(C3=C(C=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)OC)C5=CC= CC=C5
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InChiInChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
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InChi KeyDAPAQENNNINUPW-IDAMAFBJSA-N
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MSDS AvailableYes
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Gene target
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Short nameRocaglamide
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Alternative nameRocaglamide
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