Rocaglamide

  • Catalog number
    1863-100
  • Price
    Please ask
  • Size
    100 ug
  • Alternative_name
    Rocaglamide A
  • Description
    An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.
  • CAS Number
    84573-16-0
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₉H₃₁NO₇
  • Molecular Weight
    505.56
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO or EtOH
  • Handling
    Protect from air and light
  • Tag Line
    An immunosuppressant
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD08702699
  • PubChem CID
    331783
  • SMILES
    CN(C)C(=O)C1C(C2(C(C1O)(C3=C(C=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)OC)C5=CC= CC=C5
  • InChi
    InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
  • InChi Key
    DAPAQENNNINUPW-IDAMAFBJSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Rocaglamide
  • Alternative name
    Rocaglamide
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