EPZ-5676
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Catalog number2382-5
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PricePlease ask
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Size5 mg
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Alternative_name(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
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DescriptionA potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM). EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and MLL-fusion target gene expression and displays potent cell killing selective for acute leukemia lines bearing MLL translocations.
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CAS Number1380288-87-8
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₃₀H₄₂N₈O₃
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Molecular Weight562.71
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~ 25 mg/ml)
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HandlingProtect from light and air
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Tag LineA potent DOT1L inhibitor
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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SMILESCC(C)(C)C1=CC2=C(NC(CC[C@H]3C[C@@H](N(C[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C(N=CN=C6C6N)=C6N=C5)O4)C(C)C)C3)=N2)C=C1
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InChiInChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1
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InChi KeyLXFOLMYKSYSZQS-LURJZOHASA-N
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MSDS AvailableYes
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Gene target
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Short nameEPZ-5676
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Alternative nameEPZ-5676
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