EPZ-5676

• Catalog number
  2382-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
• Description
  A potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM). EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and MLL-fusion target gene expression and displays potent cell killing selective for acute leukemia lines bearing MLL translocations.
• CAS Number
  1380288-87-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₄₂N₈O₃
• Molecular Weight
  562.71
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 25 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A potent DOT1L inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• SMILES
  CC(C)(C)C1=CC2=C(NC(CC[C@H]3C[C@@H](N(C[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C(N=CN=C6C6N)=C6N=C5)O4)C(C)C)C3)=N2)C=C1
• InChi
  InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1
• InChi Key
  LXFOLMYKSYSZQS-LURJZOHASA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  EPZ-5676  
• Short name
  EPZ-5676
• Alternative name
  EPZ-5676

Similar products