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EPZ 5676

EPZ 5676 is available 2 times from Biovision labs

2382-5 | EPZ-5676 size: 5 mg | 636.19 USD

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2382-1 | EPZ-5676 size: 1 mg | 205.30 USD

Catalog number 2382-1
Supplier Biovision
Price 205.30 USD
Size 1 mg
Product images
    EPZ-5676
Alternative_name (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
Description A potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM). EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and MLL-fusion target gene expression and displays potent cell killing selective for acute leukemia lines bearing MLL translocations.
CAS Number 1380288-87-8
Structure Available? Yes
Salt Form No
Molecular Formula C₃₀H₄₂N₈O₃
Molecular Weight 562.71
Cell-Permeable? Yes
Purity ≥98% by HPLC
Solubilities DMSO (~ 25 mg/ml)
Handling Protect from light and air
Tag Line A potent DOT1L inhibitor
Storage Condition -20 ̊C
Shipping Condition gel pack
Shelf Life 36 months
SMILES CC(C)(C)C1=CC2=C(NC(CC[[email protected]]3C[[email protected]@H](N(C[[email protected]@H]4[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N5C(N=CN=C6C6N)=C6N=C5)O4)C(C)C)C3)=N2)C=C1
InChi InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1
InChi Key LXFOLMYKSYSZQS-LURJZOHASA-N
MSDS Available Yes
Gene targetEPZ-5676
Short name EPZ-5676
Alternative name EPZ-5676
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EPZ-5676 | Technique alternative | 01022198714 - Gentaur.com
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