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JNJ 10198409 for cell activation

JNJ 10198409 for cell activation is available 2 times from Biovision labs

B1078-5 | JNJ-10198409 for cell activation size: 5 mg | 258.68 USD

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B1078-25 | JNJ-10198409 for cell activation size: 25 mg | 855.11 USD

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Other name 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine, RWJ 540973
Supplied with N/A
Description JNJ-10198409 is a potent, cell-permeable, ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC₅₀ values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase. Displays less activity towards Lck, c-Src, and Fyn while exhibiting little to no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR.
Category Biochemicals
Molecular formula C₁₈H₁₆FN₃O₂
Is it cell-permeable? Yes
Molecular weight 325.34
Storage condition -20°C
Shipping condition gel pack
Purification ≥98% by HPLC
Peptide sequence N/A
Is this a salt? No
CAS number 627518-40-5
Storage instructions Protect from air and light
Maximum time for storage 36 months
Physical appearance Off-white solid
Reconstitute instructions DMSO (>10 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Short name JNJ-10198409 for activation
Technique activation
Alternative name JNJ-10198409 to measure cellular activation
Tissue cell
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