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JNJ 10198409 for cell activation

JNJ 10198409 for cell activation is available 2 times from Biovision labs

B1078-5 | JNJ-10198409 for cell activation size: 5 mg | 253.64 USD

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B1078-25 | JNJ-10198409 for cell activation size: 25 mg | 838.45 USD

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Description JNJ-10198409 is a potent, cell-permeable, ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC₅₀ values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase. Displays less activity towards Lck, c-Src, and Fyn while exhibiting little to no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR.
Peptide sequence N/A
CAS number 627518-40-5
Molecular weight 325.34
Category Biochemicals
Other name 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine, RWJ 540973
Molecular formula C₁₈H₁₆FN₃O₂
Physical appearance Off-white solid
Supplied with N/A
Is this a salt? No
Is it cell-permeable? Yes
Purification ≥98% by HPLC
Reconstitute instructions DMSO (>10 mg/ml)
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 36 months
Storage instructions Protect from air and light
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetJNJ-10198409 for activation
Short name JNJ-10198409 for activation
Technique activation
Alternative name JNJ-10198409 to measure cellular activation
Tissue cell
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