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anti-MBD2/3 (Clone 106B691) Antibody

anti-MBD2/3 (Clone 106B691) Antibody is available 1 time from Biovision labs

6104-50 | anti-MBD2/3 (Clone 106B691) Antibody size: MBD2/3 (Clone 106B691) Antibody | 358.48 USD

Catalog number 6104-50
Supplier Biovision
Price 358.48 USD
Size MBD2/3 (Clone 106B691) Antibody
1. Gene info
Identity 6917
Gene MBD2
Long gene name methyl-CpG binding domain protein 2
GenBank acession
  • AF072242
Locus 18q21.2
Discovery year 1999-01-11
Entrez gene record 8932
Pubmed identfication
  • 9774669
  • 10441743
RefSeq identity
  • NM_003927
Classification
  • Methyl-CpG binding domain containing
  • NuRD complex
  • Small nucleolar RNA protein coding host genes
Havana BLAST/BLAT OTTHUMG00000132705
Product images
    #0#.jpeg
Target of this antibody: MBD2/3
Alternative names of antibody target: Methyl-CpG-Binding Domain 2/3
Background information: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. A demethylase enzyme has been identified which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) co-localize with foci of heavily methylated satellite DNA and mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA either in vivo or in vitro. MBD1, MBD2, MBD3, and MBD4 are expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 has homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors, MBD4 is mutated at an exonic polynucleotide tract.
Antibody host: Mouse
Clonality of antibody: Monoclonal
Isotype: Mouse IgG1κ
Clone: 106B691
This antibody reacts with: Human
Immunogene sequence: Human MBD3 amino acids 215-230
Concentration of antibody: N/A
Form of antibody: Liquid
Formulation of this antibody: 50 µg in 100 µl PBS containing 0.2% gelatin and 0.05% sodium azide
Purification method: Affinity chromatography purified via peptide column (protein G)
This antibody has been succesfully tested for use in following methods: Western blot
Recommended usage: Western blot analysis (2-4 µg/ml). However, the optimal conditions should be determined individually.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetMBD2/3 106B691
Short name anti-MBD2/3 (Clone 106B691) Antibody
Technique Antibody, anti
Alternative name antibody to-MBD2/3 (clonality 106B691) (Antibody to)
Alternative technique antibodies
Clone name 106B691
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  • MBD2/3
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