PD184352
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Catalog number1585-5
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PricePlease ask
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Size5 mg
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Alternative_nameCI-1040
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DescriptionA highly potent ATP-noncompetitive MEK inhibitor. It inhibits MEK with an in vitro IC₅₀ of 1-1.3 nM. It does not inhibit other kinases. Highly recommended tool to inhibit MKK1 or MKK1 plus MKK5.
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CAS Number212631-79-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₇H₁₄ClF₂IN₂O₂
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Molecular Weight478.67
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Cell PermeableYes
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Purity≥99% by HPLC
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SolubilitiesDMSO (600 mg/ml)
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HandlingProtect from light and moisture
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Tag LineA MEK inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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MDL NumberMFCD02683961
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PubChem CID6918454
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SMILESC1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
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InChiInChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
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InChi KeyGFMMXOIFOQCCGU-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short namePD184352
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Alternative namePD184352
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