SRPIN340, SR kinase inhibitor
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Catalog number
SIH-514-25MG
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Price
Please ask
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Size
25 mg
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Stock availabilitIn Stock
In Stock
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CAS number
218156-96-8
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Description
SR kinase inhibitor
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Molecular weight
349,4 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C18H18F3N3O
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
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Physical appearance
Off-white solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
2797577
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Scientific context
SRPIN340 is a selective inhibitor of serine–arginine protein kinases (SRPK). It has been shown to inhibit SRPK1, as well as, SRPK2, at higher concentrations. SRPIN340 is ATP-competitive.
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Bibliography
1. Karakama Y., et al. (2010). Antimicrobial Agents Chemo. 54(8): 3179–3186.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of SRPIN340 (SIH-514), a SR kinase inhibitor. CAS #: 218156-96-8. Molecular Formula: C18H18F3N3O. Molecular Weight: 349.4 g/mol. Chemical structure of SRPIN340, a SR kinase inhibitor (SIH-514). CAS # 218156-96-8. Molecular Formula: C18H18F3N3O.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
SRPIN340, SR kinase inhibitor
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Alternative name
SRPIN340, SR phosphorylation catalyst suppressor
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