SRPIN340, SR kinase inhibitor

  • Catalog number
    SIH-514-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    218156-96-8
  • Description
    SR kinase inhibitor
  • Molecular weight
    349,4 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C18H18F3N3O
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
  • Physical appearance
    Off-white solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    2797577
  • Scientific context
    SRPIN340 is a selective inhibitor of serine–arginine protein kinases (SRPK). It has been shown to inhibit SRPK1, as well as, SRPK2, at higher concentrations. SRPIN340 is ATP-competitive.
  • Bibliography
    1. Karakama Y., et al. (2010). Antimicrobial Agents Chemo. 54(8): 3179–3186.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of SRPIN340 (SIH-514), a SR kinase inhibitor. CAS #: 218156-96-8. Molecular Formula: C18H18F3N3O. Molecular Weight: 349.4 g/mol. Chemical structure of SRPIN340, a SR kinase inhibitor (SIH-514). CAS # 218156-96-8. Molecular Formula: C18H18F3N3O.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    SRPIN340, SR kinase inhibitor
  • Alternative name
    SRPIN340, SR phosphorylation catalyst suppressor
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