LGR5 Antibody

• Catalog number
  A1007-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  LGR5
• Target Alternative Name
  Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR49, GPR67
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse, Rat
• Immunogen Sequence
  synthetic human LGR5 peptide (Ile685 - Pro720)
• Accession
  O75473
• Gene Id
  8549
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  100 µl antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Purification
  Affinity purified rabbit IgG
• Application
  Western Blot, Immunofluorescent staining, Immunohistochemistry, Flow cytometry
• Positive Control
  Western blot
• Application And Usages
  Western Blot 1:1000; Immunofluorescent staining 1:100; Immunohistochemistry 1:25; Flow cytometry 1:25
• Description
  Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LGR5  
• Gene symbol
  LGR5
• Short name
  LGR5 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  LGR5 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4504
• Gene
  LGR5
• Long gene name
  leucine rich repeat containing G protein-coupled receptor 5
• Synonyms gene
  • GPR67
  • GPR49
• Synonyms gene name
  • G protein-coupled receptor 49
• Synonyms
  • HG38
  • FEX
• GenBank acession
  • AF062006
• Locus
  12q21.1
• Discovery year
  1999-10-22
• Entrez gene record
  8549
• Pubmed identfication
  • 9642114
• RefSeq identity
  • NM_003667
• Classification
  • G protein-coupled receptors, Class A orphans
• VEGA ID
  OTTHUMG00000169543

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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