Aclacinomycin A hydrochloride

  • Catalog number
    B1905-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    Aclarubicin hydrochloride
  • Description
    Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.
  • CAS Number
    75443-99-1
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₄₂H₅₃NO₁₅ • HCl
  • Molecular Weight
    848.3
  • Cell Permeable
    Yes
  • Purity
    ≥90% by HPLC
  • Solubilities
    DMSO (~ 30 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A specific inhibitor of the 20S proteasome chymotrypsin-like activity.
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD00133024
  • PubChem CID
    153751
  • SMILES
    CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O.Cl
  • InChi
    InChI=1S/C42H53NO15.ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29;/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3;1H/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+;/m0./s1
  • InChi Key
    KUSMIBXCRZTVML-PCCPLWKKSA-N
  • MSDS Available
    Yes
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