Aclacinomycin A hydrochloride
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Catalog numberB1905-5
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PricePlease ask
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Size5 mg
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Alternative_nameAclarubicin hydrochloride
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DescriptionAclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.
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CAS Number75443-99-1
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₄₂H₅₃NO₁₅ • HCl
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Molecular Weight848.3
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Cell PermeableYes
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Purity≥90% by HPLC
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SolubilitiesDMSO (~ 30 mg/ml)
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HandlingProtect from air and light
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Tag LineA specific inhibitor of the 20S proteasome chymotrypsin-like activity.
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD00133024
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PubChem CID153751
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SMILESCCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O.Cl
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InChiInChI=1S/C42H53NO15.ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29;/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3;1H/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+;/m0./s1
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InChi KeyKUSMIBXCRZTVML-PCCPLWKKSA-N
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MSDS AvailableYes
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Gene target
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Short nameAclacinomycin A hydrochloride
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Alternative nameAclacinomycin A hydrochloride
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